Math and Dosage Calculations for Health Care 3rd Edition by James Whaley, Kathryn Booth, Booth Kathryn

تمرين 48

The patient: 91-year-old male, 6? 1? tall, 177 lb, CL CR of 54 mL/min.
Ordered: Acyclovir sodium (Zovirax) 750 mg IV q8h infused over 1 hr
On hand: Zovirax for Injection, 50 mg/mL when reconstituted
According to the package insert, the recommended dose for this diagnosis for patients with normal renal function is 10 mg/kg q8h. The dose is adjusted as follows for patients with impaired renal function: For creatinine clearance over 50 mL/min, 100% of the recommended dose every 8 hours; from 25-50 mL/min, 100% of the recommended dose every 12 hours; from 10-25 mL/min, 100% of the recommended dose every 24 hours; for 0-10 mL/min, 50% of the recommended dose every 24 hours.