Concepts of Biology 1st Edition by Samantha Fowler, Rebecca Roush, James Wise,OpenStax

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Figure 17.17 The Rh antigen is found on Rhpositive red blood cells. An Rh-negative female can usually carry an Rh-positive fetus to term without difficulty. However, if she has a second Rh-positive fetus, her body may launch an immune attack that causes hemolytic disease of the newborn. Why do you think hemolytic disease is only a problem during the second or subsequent pregnancies?