Biology 1st Edition by Jung Choi, Jean DeSaix, Yael Avissar, Vladimir Jurukovski, Robert Wise,Connie Rye, OpenStax

تمرين 15

Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib?
a. Signaling molecule binding, dimerization, and the downstream cellular response.
b. Dimerization, and the downstream cellular response.
c. The downstream cellular response.
d. Phosphatase activity, dimerization, and the downsteam cellular response.