Becker's World of the Cell 9th Edition by Lewis Kleinsmith, Jeff Hardin, Gregory Paul Bertoni

تمرين 7

Role of Cyclin-Dependent Protein Kinases. Based on your understanding of the regulation of the eukaryotic cell cycle, how could you explain each of the following experimental observations
(a)When mitotic Cdk-cyclin is injected into cells that have just emerged from S phase, chromosome condensation and nuclear envelope breakdown occur immediately, rather than after the normal G2 delay of several hours.
(b)When an abnormal, indestructible form of mitotic cyclin is introduced into cells, they enter into mitosis but cannot emerge from it and reenter G1 phase.
(c)Mutations that inactivate the main protein phosphatase used to catalyze protein dephosphorylations cause a long delay in the reconstruction of the nuclear envelope that normally takes place at the end of mitosis.