Essential Genetics 6th Edition by Daniel Hartl

تمرين 9

How many clones are needed to establish a library of DNA from a species of grasshopper with a diploid genome size of
base pairs if (1) fragments of average size
base pairs are used, and (2) one wants 95 percent of the genomic sequences to be in the library? ( Hint: If the genome is cloned at random with x -fold coverage, the probability that a particular sequence will be missing is