In familial retinoblastoma, there is an average of three retinal tumors per heterozygous carrier of the mutation. Assuming that the number of retinal cells at risk is 11eb71fd_c99c_99a1_a6e4_1fb5816b88e1_SM1238_00 in each eye and that each tumor results from an independent loss of heterozygosity, what is the estimated rate of loss of heterozygosity per cell? Should this be regarded as a "mutation rate"? Why or why not?

Essential Genetics 6th Edition by Daniel Hartl

النسخة 6الرقم المعياري الدولي: 978-1449686482

Essential Genetics 6th Edition by Daniel Hartl

النسخة 6الرقم المعياري الدولي: 978-1449686482

تمرين 4

In familial retinoblastoma, there is an average of three retinal tumors per heterozygous carrier of the mutation. Assuming that the number of retinal cells at risk is

in each eye and that each tumor results from an independent loss of heterozygosity, what is the estimated rate of loss of heterozygosity per cell? Should this be regarded as a "mutation rate"? Why or why not?

التوضيح

موثّق

Retinoblastoma has a familial type that ...