Essential Genetics 6th Edition by Daniel Hartl

تمرين 12

Human papilloma virus (HPV) is present in greater than 90 percent of cervical cancers. HPV encodes two proteins, E6 and E7, that are potent contributors to its tumorigenicity. E7 is known to disable RB; E6 binds to p53 and targets it for degradation. Discuss how these activities might contribute to the development of the cancerous state in infected cells.