Essential Genetics 6th Edition by Daniel Hartl

تمرين 9

A man with normal parents whose brother has phenylketonuria marries a phenotypically normal woman. In the general population, the incidence of phenylketonuria at birth is approximately 1 in 10,000. Assuming Hardy-Weinberg proportions:
(a) What is the probability that the man is a carrier?
(b) What is the probability that the wife is also a carrier?
(c) What is the probability that their first child will be affected?