Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

تمرين 6

Which of the following mutational changes would you predict to be the most deleterious to gene function? Explain your answers. 1. Insertion of a single nucleotide near the end of the coding sequence. 2. Removal of a single nucleotide near the beginning of the coding sequence. 3. Deletion of three consecutive nucleotides in the middle of the coding sequence. 4. Substitution of one nucleotide for another in the middle of the coding sequence.