Molecular Biology Of The Cell 6th Edition by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

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Both hsp60-like and hsp70 molecular chaperones share an affinity for exposed hydrophobic patches on pro- teins, using them as indicators of incomplete folding. Why do you suppose hydrophobic patches serve as critical sig- nals for the folding status of a protein?