Biomedical Engineering: Bridging Medicine and Technology 1st Edition by Veronique Tran,Mark Saltzman

تمرين 4

Glutamic acid (1 of the 20 amino acids) has a side-chain carboxyl group as shown in Figures 4.7 and 4.8.
a. Write the chemical equation for the dissociation of the side-chain COOH. Label the weak acid and the conjugate base.
b. The Henderson-Hasselbalch equation can be used to determine the ionization status of a weak acid: Use the Henderson-Hasselbalch equation to determine whether the glutamic acid side-chain carboxyl group is protonated or deprotonated at physiolo- gical pH.