Deck 9: Nutritional Supplements and Nutraceuticals

Question 1

A low-carbohydrate,high-protein diet may:

A) Increase drug-metabolizing enzymes
B) Decrease drug absorption from the GI tract
C) Alter drug binding to plasma proteins
D) Enhance drug elimination

Answer 1

Increase drug-metabolizing enzymes

Question 2

Isoniazid (INH)may induce a deficiency of which vitamin?

A) Vitamin B₆
B) Vitamin C
C) Vitamin D
D) Vitamin E

Answer 2

Vitamin B₆

Question 3

The American Heart Association (AHA)and the ADA recommend a minimum daily fiber intake of for cardiovascular health:

A) 10 mg/day
B) 15 mg/day
C) 20 mg/day
D) 25 mg/day

Answer 3

25 mg/day

Question 4

Cruciferous vegetables may alter drug pharmacokinetics by:

A) Enhancing absorption of weakly acidic drugs
B) Altering CYP 3A4 activity,leading to elevated levels of drugs,such as the statins
C) Inducing CYP 1A2,possibly leading to therapeutic failure of drugs metabolized by CYP 1A2
D) Decreasing first pass metabolism of drugs

Question 5

Grapefruit juice contains furanocoumarins that have been found to:

A) Alter absorption of drugs through competition for binding sites
B) Inhibit CYP 3A4,leading to decreased first pass metabolism of drugs
C) Alter vitamin K metabolism,leading to prolonged bleeding
D) Enhance absorption of calcium and vitamin D

Question 6

Food can alter the pH of the stomach,leading to:

A) Enhanced drug metabolism
B) Altered vitamin K absorption
C) Increased vitamin D absorption
D) Altered drug bioavailability

Question 7

Phenytoin decreases folic acid absorption by:

A) Altering the pH of the stomach
B) Increasing gastric emptying time
C) Inhibiting intestinal enzymes required for folic acid absorption
D) Chelation of the folic acid into inactive ingredients

Question 8

Which of the following vitamin or mineral supplements may by teratogenic if a pregnant woman takes more than the recommended amount?

A) Iron
B) Vitamin A
C) Vitamin B₆
D) Vitamin C

Question 9

Patients taking warfarin need to be educated about the vitamin K content of foods to avoid therapeutic failure.Foods high in vitamin K that should be limited to no more than one serving per day include:

A) Spinach
B) Milk
C) Romaine lettuce
D) Cauliflower

Question 10

Tetracycline needs to be given on an empty stomach because it chelates with:

A) Calcium
B) Magnesium
C) Iron
D) All of the above

Question 11

Food in the gastrointestinal tract affects drug absorption by:

A) Altering the pH of the colon,which decreases absorption
B) Competing with the drug for plasma proteins
C) Altering gastric emptying time
D) Altering the pH of urine

Question 12

Vitamin B₂(riboflavin)may be prescribed to:

A) Decrease the incidence of beriberi
B) Reduce headaches and migraines
C) Prevent pernicious anemia
D) Treat hyperlipidemia

Question 13

The most frequent type of drug-food interaction is:

A) Food causing increased therapeutic drug levels
B) Food affecting the metabolism of the drug
C) Food altering the volume of distribution of drugs
D) Food affecting the gastrointestinal absorption of drugs

Question 14

Milk and other foods that alkalinize the urine may:

A) Result in basic drugs being reabsorbed in the renal tubule
B) Increase the elimination of basic drugs in the urine
C) Decrease the elimination of acidic drugs
D) Not alter drug elimination due to the minimal change in urine pH

Question 15

The American Dietetic Association (ADA)recommends pregnant women take a supplement including:

A) 1000 IU daily of vitamin D
B) 2.4 mcg/day of vitamin B₁₂
C) 600 mcg/day of folic acid
D) 8 mg/day of iron

Question 16

Fasting for an extended period can:

A) Increase drug absorption due to lack of competition between food and the drug
B) Alter the pH of the gastrointestinal tract,affecting absorption
C) Cause vasoconstriction,leading to decreased drug absorption
D) Shrink the stomach,causing decreased surface area for drug absorption

Question 17

Vitamin B₁₂ deficiency may lead to:

A) Hair loss
B) Insomnia
C) Dry scales on the scalp
D) Numbness and tingling of the hands

Question 18

Antacids such as calcium carbonate (Tums)can reduce the absorption of which of the following nutrients?

A) Protein
B) Calcium
C) Iron
D) Vitamin K

Question 19

The American Dietetic Association (ADA)has recommended the use of specific nutritional supplements in the following population(s):

A) 400 IU per day of vitamin D in all infants and children
B) 1000 IU per day of vitamin D for all pregnant women
C) 60 mg per day of iron for all adults over age 50 years
D) All of the above

Question 20

Pregnant patients who are taking isoniazid (INH)should take 25 mg/day of vitamin B₆ (pyridoxine)to prevent:

A) Beriberi
B) Peripheral neuropathy
C) Rickets
D) Megaloblastic anemia

Question 21

It is reasonable to recommend supplementation with in the treatment of hyperlipidemia.

A) Omega-3 fatty acids
B) Probiotics
C) Plant sterols
D) Calcium

Question 22

There is evidence that dietary supplementation or adequate intake of fish oils and omega-3 fatty acids have well documented:

A) Concern for developing cardiac dysrhythmias
B) Anti-inflammatory effects
C) Total cholesterol-lowering effects
D) Effects on fasting blood sugar

Question 23

Patients with iron deficiency will develop:

A) Hemolytic anemia
B) Megaloblastic anemia
C) Macrocytic-hypochromic anemia
D) Microcytic-hypochromic anemia

Question 24

Symptoms of folate deficiency include:

A) Thinning of the hair
B) Bruising easily
C) Glossitis
D) Numbness and tingling of the hands and feet

Question 25

There is strong evidence to support that adequate vitamin C intake prevents:

A) The common cold
B) Breast cancer
C) Scurvy
D) All of the above

Question 26

Newborns are at risk for early vitamin K deficiency bleeding and the American Academy of Pediatrics recommends that all newborns receive:

A) IM vitamin K (phytonadione)within 24 hours of birth
B) Oral vitamin K supplementation in the first 3 weeks of life
C) Formula containing vitamin K or breast milk
D) Oral vitamin K in the first 24 hours after birth

Question 27

Adequate vitamin D is needed for:

A) Absorption of calcium from the gastrointestinal tract
B) Regulation of serum calcium levels
C) Regulation of serum phosphate levels
D) All of the above

Question 28

There is enough preliminary evidence to recommend that children with autism receive which supplemental nutrient?

A) Vitamin B₁ (thiamine)
B) Vitamin B₂ (riboflavin)
C) Calcium
D) Omega-3 fatty acids

Question 29

A patient with a new onset of systolic ejection murmur should be assessed for which nutritional deficiency?

A) Vitamin B₁₂
B) Vitamin C
C) Folate
D) Niacin

Question 30

Smokers are at risk for vitamin C deficiency.It is recommended that smokers take vitamin C supplement.

A) 100 mg/day
B) 500 mg/day
C) 1000 mg/day
D) 35 mg/day more than nonsmokers

Question 31

There is sufficient evidence to support the use of omega-3 fatty acids to treat the following disease(s):

A) Asthma
B) Autism
C) Arthritis
D) All of the above

Question 32

According to the 2003-2006 NHANES study of dietary intake,the group at highest risk for inadequate calcium intake was:

A) Elderly (over age 60 years)
B) Teenage females
C) Teenage males
D) Preschoolers

Question 33

It is reasonable to add to a Helicobacter pylori treatment regimen to improve eradication rates of H.pylori.

A) Probiotics
B) Omega-3 fatty acids
C) Plant sterols
D) Fiber

Question 34

Probiotics are recommended to be co-administered when are prescribed:

A) Antacids
B) Antihypertensives
C) Antidiarrheals
D) Antibiotics