Question 1

Drugs commonly undergo all of the following types of metabolism in the liver EXCEPT FOR:&#10;A) Polymerization&#10;B) Conjugation&#10;C) Oxidation&#10;D) Reduction&#10;E) Hydrolysis

Accepted Answer

Polymerization is not a common process by which drugs are hepatically metabolized.

Question 2

Drugs commonly undergo all of the following types of metabolism in the liver EXCEPT FOR:&#10;A) Polymerization&#10;B) Conjugation&#10;C) Oxidation&#10;D) Reduction&#10;E) Hydrolysis

Accepted Answer

Polymerization is not a common process by which drugs are hepatically metabolized.

Question 3

Which of the following features of a drug would enhance its uptake in the GI tract?&#10;A) Polar&#10;B) Water soluble&#10;C) Ionized&#10;D) Low molecular weight&#10;E) Low concentration gradient

Accepted Answer

Of the options given, only a low molecular weight will increase uptake of a drug by the GI tract.

Question 4

Which organ contains predominantly tight intercellular junctions, thereby restricting its uptake of drugs?&#10;A) Kidney&#10;B) Liver&#10;C) Brain&#10;D) Heart&#10;E) Lungs

Accepted Answer

The brain contains tight intercellular junctions, forming the "blood-brain barrier."

Question 5

Which organ contains predominantly tight intercellular junctions, thereby restricting its uptake of drugs?&#10;A) Kidney&#10;B) Liver&#10;C) Brain&#10;D) Heart&#10;E) Lungs

Accepted Answer

The brain contains tight intercellular junctions, forming the "blood-brain barrier."

Deck 2: Pharmacokinetics: Absorption, Distribution, Metabolism, and Elimination