Question 1

Which of the following is true about the action of iodide solutions for hyperthyroid states?&#10;A) High doses of iodide cause an immediate reduction in the release of thyroid hormone.&#10;B) Iodide reduces the blood supply to the thyroid gland and makes it firmer.&#10;C) Iodide has a long half-life and greatly reduces the release of thyroid hormone for up to one month.&#10;D) Both A and B.

Accepted Answer

Both option A and B are true. High doses of iodide cause an immediate reduction in the release of thyroid hormone, and iodide reduces the blood supply to the thyroid gland and makes it firmer. However, option C is false because iodide has a short half-life, and its effect on thyroid hormone levels is usually temporary.

Question 2

What purpose do ?-blockers serve in treating thyroid disease?&#10;A) They directly lower thyroid levels.&#10;B) They are only used for well-controlled patients.&#10;C) They are used to alleviate symptoms caused by adrenergic stimulation.&#10;D) They have no clinical indication in treating thyroid disease.

Accepted Answer

$\beta$-blockers such as propranolol are used to alleviate symptoms caused by adrenergic stimulation in patients with hyperthyroidism. They do not lower thyroid levels directly nor are they only used for well-controlled patients. Therefore, option a and b are incorrect. $\beta$-blockers do have a clinical indication in treating thyroid disease, making option c the correct answer.

Question 3

Which one of the following physiological responses is not associated with thyroid hormones?&#10;A) The facilitation of normal musculoskeletal growth&#10;B) Glucose storage in the liver&#10;C) The normal development of the nervous system&#10;D) Normal lactation

Accepted Answer

Glucose storage in the liver is not directly associated with thyroid hormones. Instead, it is primarily regulated by insulin and glucagon. The other physiological responses listed (musculoskeletal growth, nervous system development, and lactation) are directly influenced by thyroid hormones.

Question 4

The clinical effects of thionamides for hyperthyroid states do not become apparent until stores of thyroid hormones become depleted,which takes about ________ days after the start of therapy.&#10;A) 2 to 3&#10;B) 5 to 7&#10;C) 7 to 14&#10;D) 21 to 28

Accepted Answer

The answer of The clinical effects of thionamides for hyperthyroid...

Question 5

Generally,L-thyroxine is preferable to liothyronine as therapy in hypothyroid states because:&#10;A) it has a longer duration of action.&#10;B) it is less cardiotoxic.&#10;C) levels are easier to monitor.&#10;D) all of the above.

Accepted Answer

L-thyroxine has a longer duration of action, which allows for less frequent dosing and more stable hormone levels. It is also less cardiotoxic than liothyronine, meaning it has less potential for adverse effects on the heart. Additionally, monitoring hormone levels is easier with L-thyroxine therapy. Therefore, all of the above reasons make L-thyroxine preferable to liothyronine as therapy in hypothyroid states.

Question 6

Radioactive iodide may be used to treat hyperthyroidism because it:&#10;A) inhibits conversion of L-thyroxine to L-triiodothyronine.&#10;B) reduces synthesis of thyroid hormones.&#10;C) destroys functional thyroid tissue.&#10;D) depletes thyroid hormone stores.

Accepted Answer

Radioactive iodide destroys functional thyroid tissue by emitting beta particles that kill the thyroid cells that take it up, leading to a decrease in thyroid hormone levels. This makes it an effective treatment for hyperthyroidism, which is characterized by an overactive thyroid gland that produces too much thyroid hormone. The other options (A, B, and D) are not accurate descriptions of how radioactive iodide works to treat hyperthyroidism.

Deck 60: Medicines and the Thyroid