Deck 6: Verrucal-Papillary Lesions

Question 1

A 1 *1 cm pedunculated lesion of the soft palate was described microscopically as being composed of projections of benign epithelium supported by small amounts of fibrovascular tissue. This describes which of the following?

A) Mixed tumor of salivary gland
B) Keratoacanthoma
C) Squamous papilloma
D) Focal fibrous hyperplasia
E) Mucous extravasation phenomenon

Answer 1

Squamous papilloma

Question 2

Significant risk of malignant transformation is associated with which of the following?

A) Papillary hyperplasia
B) Peripheral ossifying fibroma
C) Squamous papilloma
D) Focal epithelial hyperplasia (Heck's disease)
E) None of the above

Answer 2

None of the above

Question 3

Human papillomaviruses, subtypes 16 and 18, have been implicated in the etiology of which of the following?

A) Burkitt's lymphoma
B) Verrucous carcinoma
C) Carcinoma of the nasopharynx
D) Oral Kaposi's sarcoma
E) Salivary gland adenocarcinomas

Answer 3

Verrucous carcinoma

Question 4

Human papillomavirus has been found in which of the following oral lesions?

A) Verrucous carcinoma
B) Proliferative verrucous leukoplakia
C) Oral warts
D) Squamous papillomas
E) All the above

Question 5

Which of the following verrucal-papillary lesions is associated with the wearing of ill-fitting dentures and frequently Candida albicans overgrowth?

A) Papillary hyperplasia
B) Verrucous carcinoma
C) Keratoacanthoma
D) Condyloma acuminatum
E) Oral wart

Question 6

Oral squamous papillomas:

A) Are composed of squamous epithelium supported by connective tissue
B) Are rare lesions
C) Are a component of the Peutz-Jeghers syndrome
D) Have moderate malignant potential
E) Are caused by cytomegalovirus (CMV)

Question 7

Verrucous carcinoma can be a sequela of which of the following?

A) Secondary syphilis
B) Proliferative verrucous leukoplakia
C) Neurofibromatosis
D) Nevoid basal cell carcinoma syndrome
E) Verruca vulgaris

Question 8

A firm asymptomatic submucosal lump, measuring 1 * 1 cm, appeared in the posterior hard palate of a 27-year-old man. The duration of the lesion was believed to be approximately 1 month. Clinical differential diagnosis should include all of the following except:

A) Lymphoma
B) Mucocele
C) Malignant salivary gland tumor
D) Benign salivary gland tumor
E) Squamous papilloma

Question 9

Which of the more than 100 human papillomavirus subtypes have been associated with the development of human carcinomas?

A) Subtypes 2 and 6
B) Subtypes 11 and 13
C) Subtypes 16 and 18
D) Subtypes 13 and 79a
E) All the above

Question 10

Which of the following verrucal-papillary lesions is associated with chronic candidiasis and the wearing of ill-fitting dentures?

A) Verrucous carcinoma
B) Verruca vulgaris (oral wart)
C) Dysplasia
D) Keratoacanthoma
E) None of the above

Question 11

Which of the following lesions is composed predominantly of benign epithelium?

A) Denture-induced hyperplasia
B) Squamous papilloma
C) Granular cell tumor
D) Mucosal neuroma
E) None of the above

Question 12

The lesion that may spontaneously involute that mimics squamous cell carcinoma both clinically and microscopically is known as:

A) Papilloma
B) Keratoacanthoma
C) Peripheral giant cell granuloma
D) Condyloma acuminatum
E) Verruca vulgaris

Question 13

All the following statements relative to oral verrucous carcinoma are correct except:

A) May develop from proliferative verrucous leukoplakia
B) Typically metastasizes early to submandibular lymph nodes
C) Usually treated with surgery
D) Microscopically well differentiated
E) Is both exophytic and endophytic

Question 14

The pathogenesis of some verrucous carcinomas is believed to be related to which of the following factors?

A) Treponema pallidum
B) Human papillomavirus subtypes 16 and 18
C) Chronic ethanol ingestion
D) Epstein-Barr virus
E) Chronic irritation

Question 15

Oral verrucous carcinoma:

A) Is usually treated with surgery
B) May be related to the use of smokeless tobacco
C) Is microscopically well differentiated
D) Rarely metastasizes to the lung
E) All the above