Deck 5: Novel Drug Delivery Systems

Question 1

PLGA is which polymer type?

A) A diblock copolymer from the natural-origin polymer class
B) A diblock copolymer from the synthetic polyester-based polymer class
C) A triblock copolymer from the synthetic polyester-based polymer class
D) A triblock copolymer from the natural-origin polymer class

Answer 1

B

Question 2

Which of the following statements is correct regarding immediate drug release versus controlled drug release?

A) Immediate release is zero-order and controlled release is first-order.
B) Immediate release is first-order and controlled release is second-order.
C) Immediate release is zero order and controlled release is super zero-order.
D) Immediate release is first-order and controlled release is zero-order.

Answer 2

D

Question 3

Polymers can be injected.

Answer 3

True

Question 4

Protein drugs can be injected.

Question 5

What is albuterol sulfate?

A) corticosteroid
B) short-acting bronchodilator
C) long-acting bronchodilator
D) All of the above
E) None of the above

Question 6

What is Advair MDI?

A) A combination drug propellant-based aerosol of drug aerosol of ipratropium bromide (an anticholinergic) and budesonide (a corticosteroid)
B) A combination drug propellant-based aerosol of ipratropium bromide (a corticosteroid) and salmeterol xinafoate (a long-acting beta agonist)
C) A combination drug propellant-based aerosol of fluticasone propionate (a beta-agonist) and salmeterol xinafoate (an anticholinergic)
D) A combination drug propellant-based aerosol of fluticasone propionate (a corticosteroid) and salmeterol xinofoate (a short-acting beta agonist)
E) None of the above

Question 7

Tiotropium bromide is in which of the following pulmonary inhalation aerosol products?

A) Spiriva Handihaler MDI
B) Spiriva Diskus DPI
C) Spriva Turbuhaler DPI
D) Spriva Handihaler DPI
E) Spiriva Diskhaler MDI

Question 8

Pressurized gas propellant aerosols have which of the following?

A) Liquid propellant
B) Three bulk phases
C) Constant pressure as the product decreases
D) All of the above
E) None of the above

Question 9

A volatile liquid propellant has which of the following properties?

A) Is a hydrocarbon
B) A Low boiling point
C) A High vapor pressure
D) All of the above
E) None of the above

Question 10

Which of the following properties do HFAs possess?

A) High stability and is a poor solvent
B) High stability and is a good solvent
C) Low stability and is a good solvent
D) Low stability and is a poor solvent
E) None of the above

Question 11

The Montreal Protocol phased out CFCs and HFAs .

Question 12

Which statement is correct regarding the advantages of pulmonary inhalation aerosol delivery?

A) requires a high dose and has a fast onset of action
B) requires a low dose and has a slow onset of drug action
C) requires a high dose and has a slow onset of action
D) requires a low dose and has a fast onset of action
E) None of the above

Question 13

Which statement is correct regarding non-invasive vs. invasive pulmonary administration?

A) Inhalation aerosol delivery is invasive and not patient-friendly
B) Intra-tracheal instillation is non-invasive and is patient-friendly
C) Inhalation aerosol delivery is non-invasive and not patient-friendly
D) Intra-tracheal instillation is invasive and not patient-friendly
E) None of the above

Question 14

The aerodynamic diameter,d_ae,of a particle is directly proportional to which of the following parameters?

A) The square of the particle density
B) The square root of the particle geometric (linear) diameter
C) The square of the particle geometric (linear) diameter
D) The square root of the particle density
E) None of the above

Question 15

Which statement is correct regarding proper use on using a DPI Diskus device?

A) Shake well. Hold the inhaler horizontally.
B) Shake well. Hold the inhaler vertically upright
C) No shaking needed and hold the inhaler vertically upright
D) No shaking needed and hold the inhaler horizontally
E) None of the above

Question 16

Which statement is correct regarding the different modes of particle deposition in the lungs?

A) 3 major modes (interception,sedimentation,diffusion) and 2 minor modes (electrostatic attraction and impaction)
B) 3 major modes (impaction,interception,diffusion) and 2 minor modes (electrostatic attraction and sedimentation)
C) 3 major modes (interception,sedimentation,electrostatic attraction) and 2 minor modes (impaction and diffusion).
D) 3 major modes (impaction,sedimentation,diffusion) and 2 minor modes (electrostatic attraction and interception).
E) None of the above

Question 17

Sedimentation mode of particle deposition in the lung relates to patient instruction by which of the following?

A) Breath normally
B) Shake the MDI well
C) Hold the breath
D) Breath quickly
E) All of the above

Question 18

In pulmonary clearance,the removal of lung mucus by the mucociliary escalator can be altered by which of the following?

A) A change in ciliary activity
B) A change in mucus viscosity
C) The presence of Lung disease
D) All of the above

Question 19

Which statement is correct regarding inhalation aerosol vaccine delivery?

A) FluMist contains an antiviral drug and Relenza Diskhaler contains a live attenuated virus.
B) FluMist Diskhaler contains a live attenuated virus and Relenza Diskhaler contains an antiviral drug.
C) FluMist Diskhaler contains an antiviral drug and Relenza Diskhaler contains a live attenuated virus.
D) FluMist contains a live attenuated virus and Relenza Diskhaler contains an antiviral drug
E) FluMist contains a live attenuated virus and Relenza Diskhaler contains a live attenuated virus.

Question 20

Particles intended for nasal drug delivery are in what size range?

A) 1-10 microns
B) 1- 20 microns
C) 200-500 microns
D) 20-50 microns

Question 21

Which of the following prescription nasal products are used for CNS drug delivery and/or systemic drug delivery?

A) Flonase,Rhinocort,Zomig,
B) Nasalcrom,Flumist,Zomig,
C) Nicotrol NS,Zomig,Miacalcin
D) Nicotrol NS,Miacalcin,Nasonex
E) Flumist,Zomig,Veramyst

Question 22

Which statement is correct about membrane-acting permeation enhancers in nasal delivery?

A) They decrease membrane permeability.
B) They increase membrane permeability.
C) They do not affect membrane permeability.
D) They increase membrane viscosity
E) None of the above

Question 23

Which statement is true about OTC nasal irrigation products?

A) They are saline solutions without a drug
B) They are saline solutions with a drug
C) They are not saline solutions but they contain a drug
D) All of the above
E) None of the above

Question 24

Which statement is true about combination drug aerosol prescription products?

A) They always contain 2 different drugs where both drugs are from the same therapeutic class
B) They always contain 2 different drugs where each drug is from a different therapeutic class
C) They are only available as DPIs.
D) They are only available as MDIs
E) They are not available currently as prescription products.

Question 25

Which statement is true regarding combination drug aerosol prescription products?

A) They are only available as DPIs
B) They are only available as MDIs
C) They are available both as MDIs and DPIs.
D) They are not currently available as prescription products
E) All of the above

Question 26

Which statement is true about spacers?

A) They can be used with both DPIs and MDIs
B) They can only be used with DPIs but not MDIs
C) They can be used with all MDIs.
D) They can be used with certain types of MDIs but not all MDIs.
E) They can be used with certain types of DPIs but not all DPIs.

Question 27

Which statement is true about spacers?

A) The reversed-flow spacer is the simplest of spacer
B) The open-tube spacer uses reverse airflow.
C) The reservoir spacer directs the plume "with the flow".
D) The open-tube spacer does not have electrostatic particle deposition problems unlike the reversed-flow and reservoir spacers.
E) None of the above

Question 28

True-False: Nasal aerosols are used to deliver drugs to the nasal regions and the lungs

Question 29

What is albuterol sulfate?

A) short-acting bronchodilator
B) long-acting bronchodilator
C) corticosteroid
D) All of the above
E) None of the above

Question 30

What is salmeterol xinafoate?

A) short-acting bronchodilator
B) long-acting bronchodilator
C) corticosteroid
D) All of the above
E) None of the above

Question 31

Which statement is true about DPIs?

A) Powder reservoir DPIs are unit-dose DPIs.
B) Multi-unit dose DPIs are pre-metered.
C) Unit-dose DPIs are classified as third-generation DPIs
D) Unit-dose DPIs are classified as second-generation DPIs
E) Powder reservoir DPIs always have lactose carrier particles