Deck 7: Hematopoiesis

Question 1

When hematopoiesis occurs in the liver in an adult,it is called:

A)intramedullary.
B)intermedullary.
C)normal.
D)extramedullary.

Answer 1

extramedullary.

Question 2

All of the following functions are performed by cytokines except

A)stimulating production of blood cells.
B)inducing macrophages to attack senescent cells.
C)regulating cell differentiation.
D)monitoring trafficking of mature blood cells.

Answer 2

inducing macrophages to attack senescent cells.

Question 3

Enlarged lymph nodes are commonly found in all of the following except

A)viral infections.
B)liver cirrhosis.
C)bacterial infections.
D)metastatic malignancy.

Answer 3

liver cirrhosis.

Question 4

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found after surgical removal of the spleen?

A)Blood loss from surgery increases erythrocyte production.
B)Necessary hematopoiesis growth factors produced in the spleen are lost.
C)Removal of the spleen induces the formation of inclusions.
D)The absent spleen cannot "pit" or remove the normally formed inclusions.

Question 5

The thymus is responsible for the initial development of

A)macrophages.
B)T cells.
C)B cells.
D)neutrophils.

Question 6

Why does surgical removal of the spleen cause people to have an increased platelet count?

A)The bone marrow makes more platelets when the person has no spleen.
B)The 30% of platelets normally stored in the spleen are freely circulating.
C)Antibodies produced after splenectomy attack platelets.
D)Surgery stimulates platelet growth factors.

Question 7

Where are developing red cells located in the bone marrow?

A)adjacent to the outer surfaces of the vascular sinuses
B)outside the vascular walls of the sinusoids
C)deep in the cords
D)randomly spaced throughout the cords

Question 8

Which of the following is a morphologically identifiable precursor cell using Wright stain?

A)promyelocyte
B)colony-forming unit-erythrocyte (cfu-e)
C)colony-stimulating factor-granulocyte-monocyte (CSF-GM)
D)HSC

Question 9

What bone marrow cells can differentiate into all of the blood cells?

A)burst-forming unit-erythroid (BFU-E)
B)colony-forming unit-granulocyte-monocyte (CFU-GM)
C)colony-forming unit-granulocyte, erythrocyte, monocyte, and megakaryocyte (CFU-GEMM)
D)hematopoietic stem cells (HSCs)

Question 10

How do cells get from the bone marrow into peripheral circulation?

A)Stem cells escape the bone marrow and mature in peripheral circulation.
B)Mature cells attach to a carrier protein for transport.
C)Capillaries flow into the marrow and pluck out precursor cells.
D)Mature cells squeeze through spaces in the vessel endothelial lining.

Question 11

How many blood cells are made each day in the bone marrow of a normal adult?

A)thousands
B)millions
C)about 1 billion
D)hundreds of billions

Question 12

Apoptosis is

A)enhanced red cell production.
B)programmed cell death.
C)directed exit of cells from the bone marrow.
D)accidental cell death from trauma.

Question 13

Germinal centers in lymph nodes contain primarily

A)B cells.
B)macrophages.
C)neutrophils.
D)T cells.

Question 14

All of the following are functions of macrophages in the bone marrow except

A)activating adipose cells.
B)secreting cytokines.
C)storing iron.
D)phagocytizing senescent cells.

Question 15

Kupffer cells,found in the liver,are

A)adipose cells.
B)macrophages.
C)immature red cells.
D)immature granulocytes (neutrophils).

Question 16

Which of the following,using Wright stain,is a feature of normal cells as they mature?

A)overall size increases
B)nucleoli become more prominent
C)nuclear chromatin becomes more condensed
D)cytoplasmic basophilia increases

Question 17

Which of the following is a hematopoietic growth factor?

A)interleukin
B)BFU-E
C)fibroblast
D)HSC

Question 18

What is the primary mechanism for the anemia associated with kidney disease?

A)hemolysis
B)hemorrhage
C)inadequate synthesis of erythropoietin
D)inadequate synthesis of interleukins

Question 19

What condition is most associated with autosplenectomy?

A)abdominal trauma
B)thrombocytopenia
C)sickle cell anemia
D)iron deficiency

Question 20

What are the major hematopoietic sites in the fetus and in the adult?
FetusAdult

A)lymph node spleen
B)liver bone marrow
C)liver spleen
D)bone marrow liver

Question 21

Colony-stimulating factors

A)have poor affinity for their target cells.
B)require high concentrations to be effective.
C)are produced by many cells.
D)are all lineage specific.