Deck 37: Epidemiology of Leukemia

Question 1

During the past three decades, the annual number of new cases of leukemia increased by 75% (from 250,000 in 1990 to 437,000 in 2018), and the annual number of deaths from leukemia increased by 68% (from 184,000 in 1990 to 310,000 in 2018).

Answer 1

True

Question 2

More than 70% of deaths from leukemia occur after the age of 65 years.

Answer 2

True

Question 3

Substantial decreases in leukemia mortality occurred in children and young adults of Great Britain and the USA during the latter 20^th century.

Answer 3

True

Question 4

Acute lymphocytic leukemia accounts for about 80% of all leukemias that are diagnosed in children.

Question 5

In developed nations, the annual death rate from leukemia in children has fallen by more than 50% in the past three decades.

Question 6

Risk factors for childhood leukemia include ionizing radiation, rare genetic syndromes, and certain chemotherapeutic drugs.

Question 7

Causal factors for most cases of childhood leukemia are obscure, and the etiology remains enigmatic.

Question 8

African American children have higher rates of acute lymphocytic leukemia than Caucasian American children.

Question 9

Leukemias diagnosed in adults (20 years or older) account for nearly 90% of all cases.

Question 10

Among adults, 60% of leukemias are lymphocytic, and 40% are myelocytic.

Question 11

Approximately what percentage of leukemias are diagnosed in children or adolescents?

A) 11%
B) 20%
C) 30%
D) 40%

Question 12

Since 1970, mortality from childhood leukemia in developed nations has decreased by about:

A) 25%.
B) 50%.
C) 75%.
D) 100%.

Question 13

The risk factors for acute myelocytic leukemia include all of the following except:

A) ionizing radiation.
B) benzene-containing compounds.
C) alkylating agents and topoisomerase inhibitors used in cancer therapy.
D) immunosuppressive drugs used in organ transplantation.
E) alcohol abuse.

Question 14

What condition often precedes the development of acute myeloid leukemia?

A) Myeloid dysplastic syndrome
B) Presence of the Philadelphia chromosome
C) Sickle cell anemia
D) Klinefelters syndrome

Question 15

The defining cytogenetic abnormality in chronic myelocytic (granulocytic) leukemia is:

A) the Philadelphia chromosome.
B) trisomy 8.
C) deletion of the long arm of chromosome 6.
D) deletion of the long arm of chromosome 11.

Question 16

Significant risk factors for chronic lymphocytic leukemia include all of the following except:

A) ionizing radiation.
B) family history.
C) deletion of the long arm of chromosome 13.
D) Agent Orange.

Question 17

Hairy Cell Leukemia is characterized by all of the following except:

A) malignant cells are of B cell lineage.
B) the annual incidence is approximately 3 cases per million in men and 0.6 cases per million in women.
C) afflicted relatives have common HLA haplotypes.
D) exposure to herbicides is a significant risk factor.

Question 18

Characterize the different forms of leukemia.

Question 19

Describe the global burden of leukemia.

Question 20

Discuss the epidemiology of pediatric leukemia.

Question 21

Briefly discuss the epidemiology of acute myelocytic leukemia.

Question 22

Discuss the cytogenetics and epidemiology of chronic myelocytic leukemia in adults.

Question 23

Discuss the epidemiology of chronic lymphocytic leukemia.

Question 24

Discuss the epidemiology of hairy cell leukemia.

Question 25

Discuss the epidemiology of monocytic leukemia.