Deck 23: Epidemiology of Corpus Uterine Cancer

Question 1

Worldwide, cancer of the corpus uteri (body of the uterus) was diagnosed in 382,069 women and caused 89,929 deaths during 2012.

Answer 1

True

Question 2

The most common histologic type of corpus uterine cancer is endometrial cancer.

Answer 2

True

Question 3

Most cases (over 85%) of endometrial cancer are diagnosed in women living in underdeveloped countries.

Answer 3

False

Question 4

The global pattern of endometrial cancer is similar to breast cancer.

Question 5

Type 1 endometrial carcinomas are estrogen-dependent and positive for estrogen receptors.

Question 6

Estrogen replacement therapy is a significant risk factor for the development of endometrial cancer.

Question 7

Early menarche, nulliparity, and late menopause have all been consistently found to increase the risk of developing endometrial cancer.

Question 8

Obesity does not increase the risk of developing endometrial cancer.

Question 9

What fraction of corpus uterine malignancies are endometrial carcinomas?

A) 55%
B) 65%
C) 75%
D) 92%

Question 10

Type 1 endometrial carcinomas exhibit all of the following except:

A) estrogen receptors.
B) HPV infection.
C) progesterone receptors.
D) dependence on estrogen for development.

Question 11

Risk factors for endometrial cancer include all of the following except:

A) nulliparity.
B) late age at first pregnancy.
C) exposure to tamoxifen.
D) cigarette smoking.

Question 12

Type 2 endometrial carcinomas exhibit all of the following except:

A) estrogen receptors are absent.
B) they do not depend on estrogen for growth and development.
C) they account for about 10% of all endometrial carcinomas.
D) survival of cases is high.

Question 13

Which of the following statements are true about leiomyoma (uterine fibroids)?

A) Uterine fibroids are benign tumors.
B) Uterine fibroids are the most common of all tumors in women.
C) Risk factors for uterine fibroids are similar to breast cancer and endometrial cancer.
D) All of the above are correct.

Question 14

Describe the global burden of corpus uterine cancer.

Question 15

Discuss global time trends in the incidence and mortality of corpus uterine cancer.

Question 16

Discuss the risk factors for endometrial cancer.

Question 17

Discuss the pathogenesis of endometrial cancer according to the "estrogen window" hypothesis.

Question 18

Discuss the epidemiology of leiomyosarcoma of the uterus.

Question 19

Discuss the etiology of choriocarcinomas.