Question 1

Tumor necrosis factor inhibitors ________________.&#10;A)include etanercept, adalimumab and infliximab&#10;B)are used orally or by injection&#10;C)have also been shown to reduce the risk of infections&#10;D)All of the above

Accepted Answer

They are injected and self-injection (with etanercept)can become a problem because patients might not have the expertise to do so.They can disseminate infections and reactivate a dormant tuberculosis,and it is now recommended to perform an x-ray and do skin testing before the start of therapy.

Question 2

Chronic use of corticosteroids can cause ________________.&#10;A)osteoporosis&#10;B)fat loss&#10;C)alopecia&#10;D)All of the above

Accepted Answer

It causes also skin thinning and muscle wasting as well as cataracts,increased intraocular pressure,fat shifts (moon face,buffalo hump),poor wound healing,increased risk of infections and stomach ulcers.To counteract osteoporosis,supplementation with Calcium and vitamin D is recommended.

Question 3

Which of the following drug classes is used in the treatment of RA?&#10;A)Gold compounds to reduce the immune response&#10;B)NSAIDs drugs to reduce inflammation&#10;C)Antibiotics to slow the infectious process&#10;D)All of the above

Accepted Answer

Gold compounds are effective but cause serious adverse reactions and are not or only rarely used anymore.The same holds true for cyclosporine and cyclophosphamide.Antibiotics are not used.However,anti-rheumatic drugs to alter the disease and corticosteroids to reduce inflammation are also used.

Question 4

Drug induced SLE ________________.&#10;A)starts often with red patches on skin&#10;B)is irreversible even if recognized early&#10;C)is at present only associated with some anti-cancer drugs&#10;D)All of the above

Accepted Answer

The physical therapist should look for redness and rashes in patients receiving drugs.If recognized early,drug induced SLE is reversible.It is associated with many drugs and the estimates range from 80 to 400 drugs.

Question 5

Which one of the following statements is correct?&#10;A)Probenicid and sulfinpyrazone increase renal uric acid excretion.&#10;B)Increased fluid intake is ineffective since it does not increase uric acid secretion.&#10;C)Allopurinol increases the metabolism of uric acid by the body.&#10;D)All of the above

Accepted Answer

Increased fluid intake increases uric acid elimination and sufficient fluid must be provided during exercise and sweating in patients with gout.Allopurinol decreases uric acid formation.

Question 6

Therapists should observe patients being treated with anti-rheumatic drugs for ________________.&#10;A)skin rashes&#10;B)easy bruising&#10;C)dehydration&#10;D)All of the above

Accepted Answer

Many drugs can cause skin rashes which sometimes are early warning signs of major health problems.Neutropenia can lead to bleeding episodes.Patients should be well hydrated to increase renal elimination of some toxic metabolites of these drugs.

Question 7

Which one of the following statements is false?&#10;A)Indomethacin is used frequently to reduce the inflammation and pain of acute gout.&#10;B)Patients who do not respond to indomethacin or colchicine can be treated with prednisone.&#10;C)Thiazide diuretics are often added to indomethacin to increase uric acid excretion by the kidneys.&#10;D)Low doses of aspirin can decrease uric acid excretion by the kidneys.

Accepted Answer

Thiazide diuretics retain uric acid and can elevate blood uric acid levels.High doses of aspirin are uricosuric while low doses retain uric acid.

Question 8

Rheumatoid arthritis or RA ________________.&#10;A)is an inflammatory disease&#10;B)is usually confined to joints&#10;C)and its inflammation of the synovial linings is thought to be caused by B-cells&#10;D)All of the above

Accepted Answer

RA is associated with vasculitis,pleural effusion,pericarditis and lymphadenopathy.It is genetically linked to the histocompatibility complex and its interaction with T cells.

Question 9

Which one of the following statements is true?&#10;A)NSAIDs are designed to bridge the gap between steroids and DMARDs.&#10;B)NSAIDs are the only drugs which slow the progression of RA.&#10;C)Anti-rheumatic drugs have a slow onset of action.&#10;D)DMARDs include celecoxib, diclofenic, and naproxen.

Accepted Answer

NSAIDs have a quick onset of action and reduce signs but do not affect the progression of the disease.Anti-rheumatic drugs might not cause a clinical response until 3-6 months of use.

Question 10

Which one of the following statements concerning methotrexate is false?&#10;A)It should only be used as monotherapy.&#10;B)It can cause some hepatotoxicity.&#10;C)NSAIDs can increase the drug's adverse reactions.&#10;D)It can reduce the risk of cardiac mortality linked to RA.

Accepted Answer

The drug is often combined with other anti-rheumatic drugs with the combination showing greater efficacy.The low dose during treatment of RA shows relatively few adverse reactions except hepatotoxicity (blood tests for liver enzymes are indicated),cramping and alopecia.NSAIDs are most damaging in older individuals with decreased renal function.

Question 11

Gout ________________.&#10;A)is caused by crystalline deposits in a joint&#10;B)is always associated with an enzyme deficiency&#10;C)shows usually a slow onset and a long duration of action&#10;D)occurs more frequently in older men and younger women

Accepted Answer

The answer of Gout ________________.&#10;A)is caused by crystalline deposits in...

Question 12

Leflunomide is ________________.&#10;A)a prodrug&#10;B)more effective than methotrexate&#10;C)used as mono-therapy&#10;D)associated with pulmonary edema

Accepted Answer

The answer of Leflunomide is ________________.&#10;A)a prodrug&#10;B)more effective than methotrexate&#10;C)used...

Question 13

Occurrence of a black stool during NSAIDs therapy is a sign of bleeding from ________________.&#10;A)the rectum&#10;B)the stomach or intestines&#10;C)the liver&#10;D)A and B are correct

Accepted Answer

The answer of Occurrence of a black stool during NSAIDs...

Deck 12: Drug Treatment for Arthritis-Related Conditions