Deck 13: Selective Topics in Endocrine Pharmacology

Question 1

Which one of the following statements is false?

A)Iodide at large doses can prevent its uptake into the thyroid gland.
B)The secretion of the thyroid stimulating hormone or TSH from the pituitary gland increases thyroid hormone production.
C)Hyperthyroidism manifests as tachycardia, excitation, heat intolerance, tremor, exophthalmos and weight loss.
D)Propylthiouracil inhibits the synthesis of the thyroid hormones T4 and T3.

Answer 1

The secretion of the thyroid stimulating hormone or TSH from the pituitary gland increases thyroid hormone production.

Question 2

You are seeing a patient in therapy who is on replacement therapy for hypothyroidism.Which one of the following responses or observations indicates that this patient's level of thyroid hormone may be too elevated?

A)Heat intolerance during aquatic therapy
B)Cold intolerance with an ice pack
C)Dry, flaky skin noted during a back massage
D)Bradycardia during a treadmill test

Answer 2

Heat intolerance during aquatic therapy

Question 3

Oral contraceptives (estrogen,progestin drugs)________________.

A)cause a sperm hostile environment through estrogen's action
B)inhibit the secretion of FSH and LH and prevent follicular development
C)contain mostly ethylestrenol
D)contain mostly stanozolol

Answer 3

inhibit the secretion of FSH and LH and prevent follicular development

Question 4

Which of the following activities is contraindicated for a woman on fertility drugs (menotropins)?

A)Whirlpool of the foot
B)Exercises for the knee on the Cybex
C)PNF exercises for the upper extremity
D)Measuring aerobic capacity on a treadmill

Question 5

Levothyroxine ________________.

A)is converted to T4 as the active form
B)has a wide margin of safety
C)therapy can lead to osteoporosis and fractures
D)All of the above

Question 6

The post-coital drug mifepristone ________________.

A)antagonizes the effects of androgens causing uterine contractions
B)is effective only for 14 days after unprotected intercourse
C)causes the release of estrogens which prevents egg implantation
D)acts like misoprostol

Question 7

Major side effects of oral contraceptives are ________________.

A)deep vein thrombosis
B)ischemic stroke
C)myocardial infarction
D)All of the above

Question 8

The most commonly used drugs in the treatment of acromegaly simulate which of the following hormones?

A)Growth hormone
B)ACTH
C)SST
D)Prolactin

Question 9

HRT with estrogen and medroxyprogesterone is not recommended for which of the following patients?

A)52-year-old women with recurrent colon polyps
B)60-year-old women with histories of steroid use and hip fractures
C)Postmenopausal women with strong family histories of breast cancer
D)Women undergoing menopause who are experiencing severe vasomotor instability

Question 10

Which one of the following statements concerning erectile dysfunction or ED is correct?

A)Smoking, hypertension and diabetes have only negligible effects on ED.
B)Drugs used to treat ED stimulate muscarinic receptors promoting an erection.
C)Drugs can cause a runny nose and taste disturbances.
D)Drugs can cause a dangerous drop in blood pressure when taken with nitrates.

Question 11

Plan B drug ________________.

A)uses levonorgestrel which expels the implanted egg
B)is now available on the pharmacy shelf without a prescription
C)must be taken within 72 hours
D)can terminate an existing pregnancy

Question 12

Excessive glucocorticoid secretion ________________.

A)occurs in Cushing's syndrome
B)leads to bone strengthening
C)enlarges extremities
D)is treated with prednisone to block cortisol release

Question 13

Which of the following statements is correct?

A)ACTH injections will causes a release of cortisol in Addison's disease.
B)A deficiency of the release of vasopressin can be treated with prolactin.
C)Growth hormone injections to adults without exercise have no significant effect on muscle strength.
D)All of the above

Question 14

Which of the following drugs would not be used to treat a thyroid storm?

A)Beta-blockers to reduce heart rate
B)Alpha-blockers to reduce hypertension
C)Large doses of iodide to prevent further iodide uptake
D)Propylthiouracil to decrease thyroid hormone formation

Question 15

Exogenous estrogens ________________.

A)increase the risk of manic episodes
B)increase the risk of endometrial cancer
C)decrease bone density
D)cause muscle weakness

Question 16

Which of the following is a side effect of oral contraceptive agents?

A)Ovulation
B)Gynecomastia
C)DVT
D)Improved fertility

Question 17

Hormonal estrogen replacement after menopause ________________.

A)reduces significantly hot flashes, atrophic vaginitis, osteoporosis and mood swings
B)reduces risk of cardiovascular diseases
C)does not increase the risk of breast cancer since cancer would have appeared before replacement therapy
D)is now prohibited

Question 18

Which one of the following is contraindicated for the treatment of a 52-year-old woman who suffers from vasomotor instability related to menopause and who also has high risk factors for cardiac disease?

A)Hormone replacement therapy (estrogen and medroxyprogesterone)
B)SSRIs
C)Antiepilepsy drugs
D)Phytoestrogens such as soy

Question 19

Which one of the following is associated with the exogenous intake of a steroid?

A)Lowering of blood pressure
B)Hypoglycemia
C)Immune suppression
D)Strengthening of connective tissue

Question 20

Testosterone is indicated in the treatment of anemia for which of the following reasons?

A)It facilitates the effect of growth hormone.
B)It stimulates erythropoietin release.
C)It interacts with estrogen receptors.
D)It stimulates the synthesis of protein.