Deck 18: Drug Treatment for Depression and Anxiety

Question 1

A patient treated with SSRIs might experience _______________.

A)sedation
B)orthostatic hypotension
C)arrhythmias
D)akathisia

Answer 1

akathisia

Question 2

All of the following are typical side effects of benzodiazepine except _______________.

A)unsteadiness
B)sleepiness
C)agitation
D)memory lapses

Answer 2

agitation

Question 3

Which of the following statements is correct?

A)Barbiturates but not benzodiazepines can cause physical dependence.
B)Barbiturates and benzodiazepines have the same mode of action.
C)Barbiturates and benzodiazepines can cause tolerance.
D)Benzodiazepines are more efficacious in inducing p450 enzymes.

Answer 3

Barbiturates and benzodiazepines can cause tolerance.

Question 4

Buspirone _______________.

A)acts mostly on norepinephrine receptors
B)has a delayed (about 3 weeks) onset of action
C)is more effective than the benzodiazepines but also more toxic
D)All of the above

Question 5

GABA _______________.

A)opens Na⁺ channels causing depolarization
B)opens Cl⁻ channels causing hyperpolarization
C)closes Ca⁺⁺ channels causing depolarization
D)closes Mg⁺⁺ channels causing hyperpolarization

Question 6

Which of the following is a clinical concern when treating a patient on a long-acting benzodiazepine?

A)Reduction of REM sleep
B)Ataxia leading to falls
C)Polydipsia
D)Polyphagia

Question 7

Antidepressants usually _______________.

A)have a quick onset of therapeutic action
B)have a delayed onset of therapeutic action
C)have a delayed onset of adverse reactions
D)reduce early on the risk of suicide

Question 8

Which of the following is true regarding MAO-A inhibitors?

A)They decrease the release of norepinephrine.
B)They produce a hypertensive reaction when given with fermented foods.
C)They produce CNS sedation.
D)They are more effective than the SSRIs.

Question 9

SSRIs are preferred over TCAs for which of the following reasons?

A)They are more effective at reducing symptoms of depression.
B)They lack cardiac effects.
C)They have some α-adrenergic-blocking responses.
D)They are not addictive.

Question 10

The two neurotransmitters most commonly implicated in the etiology of all anxiety disorders are ___________.

A)GABA and epinephrine
B)Gycine and GABA
C)Norepinephrine and epinephrine
D)GABA and serotonin

Question 11

All of the following can be ADRs of tricyclic treatment except _______________.

A)anticholinergic reactions
B)antihistaminic reactions
C)antiadrenergic reactions
D)antidopaminergic reactions

Question 12

The neurotransmitter system which seems to play no or only a minor role in the pathogenesis of depression is _______________.

A)a deficiency of the serotonin system
B)a deficiency of the norepinephrine system
C)excess of corticotrophin-releasing hormone
D)excessive acetylcholine

Question 13

A drug with a short half-life as compared to a drug with a long half-life will cause _______________.

A)a more rapid onset of withdrawal syndrome
B)a milder withdrawal syndrome
C)a longer withdrawal syndrome
D)the same withdrawal syndrome with both drugs

Question 14

SSRIs have _______________.

A)anticholinergic effects
B)antihistaminic effects
C)antiadrenergic effects
D)None of the above

Question 15

Adverse effects of benzodiazepines include which of the following?

A)Drowsiness
B)Dizziness
C)Reduced psychomotor performance
D)All of the above

Question 16

It is thought that most antidepressants _______________.

A)increase the synthesis of norepinephrine and/or serotonin
B)decrease the synthesis of acetylcholine and/or corticotropin-releasing hormone
C)decrease the re-uptake of norepinephrine and/or serotonin
D)increase the destruction of corticotrophin-releasing hormone and/or acetylcholine

Question 17

Which of the drug class-drug combinations is a mismatch?

A)Tricyclics - amitriptyline
B)SSRIs - fluoxetine
C)MAO inhibitors - moclobenide
D)anti-pychotic - paroxetine

Question 18

Which of the following is not associated with a benzodiazepine drug?

A)Sedation
B)Impaired hearing
C)Dizziness
D)Ataxia