Question 1

According to a critical review of the literature,which of the following dietary supplements may be modestly effective for reducing either musculoskeletal or neurologic pain in studies of short duration?

A)SAM-e
B)Capsaicin
C)Glucosamine
D)Garlic

Capsaicin

Accepted Answer

When considering factors such as size of study,research design,and outcome measures,only capsaicin has shown to produce a modest effect of pain relief.

Question 2

Side effects of topical salicylates may include which of the following?&#10;A)Potentiation of the effects of warfarin&#10;B)Visual disturbances&#10;C)Reduction of blood flow locally

Accepted Answer

These agents may potentiate the effects of warfarin.In addition they have the potential to cause salicylate poisoning consisting of nausea,vomiting,tinnitus,headache,seizure,and hyperthermia.

Question 3

A primary concern in using St.John's Wort is which of the following?&#10;A)Reduction in cognition&#10;B)Neuropsychiatric symptoms&#10;C)Multiple drug interactions&#10;D)Joint pain

Accepted Answer

St.John's Wort alters the chotochromie P450 enzymes and therefore alters the hepatic metabolism of many drugs including chemotherapeutic agents,antivirals,and some cardiovascular agents.

Question 4

Which of the following would be a legal claim for marketing a dietary supplement?&#10;A)Lowers blood pressure&#10;B)Is heart healthy&#10;C)Lowers cholesterol&#10;D)Prevents cardiovascular disease

Accepted Answer

Although this is a vague claim this is acceptable.Dietary supplements cannot claim to diagnose,treat,prevent or cure a disease.

Question 5

Which of the following may be beneficial effects of CoQ10?&#10;A)Lowers blood pressure&#10;B)Reduces the myopathy that may occur with statin drugs&#10;C)Improves exercise tolerance in patients with heart failure&#10;D)All of the above

Accepted Answer

Studies have shown that all of these may be positive effects of taking CoQ10 as well as having an anticoagulant effect.However,it is important to note studies are limited.

Question 6

The premise behind using soy isoflavones in menopause includes which of the following?&#10;A)May replace lost estrogen during menopause&#10;B)Enhances calcium release from the sarcoplasmic reticulum&#10;C)Blocks sodium channels&#10;D)Blocks sweat glands

Accepted Answer

Soy has an estrogenic effect.

Question 7

A dietary supplement can be characterized by which of the following?&#10;A)Contains tobacco&#10;B)Labeled as a drug&#10;C)Designed to supplement the diet&#10;D)Are safe to administer

Accepted Answer

Dietary supplements are intended to supplement the diet.They usually contain vitamins,minerals,amino acids or herbs.They are not considered drugs and therefore are not subject to the same rigorous regulations.There is increasing evidence that these agents have hidden side effects and may interact with prescription drugs.

Question 8

Which one of the following is contraindicated for the treatment of a 52-year-old woman who suffers from vasomotor instability related to menopause and who also has high risk factors for cardiac disease?

A)Hormone replacement therapy (estrogen and medroxyprogesterone)
B)SSRIs
C)Antiepilepsy drugs
D)Phytoestrogens such as soy

Accepted Answer

HRT is no longer recommended for use during menopause due to an increased risk of breast cancer,thrombotic effects,and stroke.

Deck 26: Complementary and Alternative Medicine in Pharmacology