Question 1

According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomach because the drug which exist primarily in the&#10;A)Unionized, more lipid soluble form&#10;B)Ionised, more water soluble form&#10;C)Form of weak acid and more soluble in acid media&#10;D)Ionic form of the drug, which facilitates diffusion

Accepted Answer

Weak acidic drugs are more likely to be absorbed from the stomach because they exist primarily in their unionized, more lipid-soluble form in the acidic environment of the stomach, facilitating their passage through the lipid bilayer of cell membranes.

Question 2

Very weak bases having pKa < 5&#10;A)Are ionized in the entire pH range of GIT&#10;B)Show absorption, which is pH dependent&#10;C)Are unionized at all pH values&#10;D)None of the above

Accepted Answer

Are unionized at all pH values&#10;

Question 3

IV route of drug administration does not involve&#8230;&#8230;&#8230;&#8230;&#10;A)distribution step&#10;B)absorption step&#10;C)biotransformation step&#10;D)All of the above

Accepted Answer

The intravenous (IV) route of drug administration bypasses the absorption step because the drug is directly introduced into the bloodstream, ensuring immediate effect. Distribution and biotransformation steps are still involved in the process.

Question 4

In carrier mediated transport energy is derived from&#8230;&#8230;..&#10;A)Hydrolysis of ATP&#10;B)Protein metabolism&#10;C)Concentration gradient&#10;D)All of the above

Accepted Answer

Carrier mediated transport, specifically active transport, derives energy from the hydrolysis of ATP to move substances against their concentration gradient.

Question 5

Which of the following drug is not stable in the gastric fluid?&#10;A)Erythromycin&#10;B)Paracetamol&#10;C)Salicylic acid&#10;D)none of the above

Accepted Answer

Erythromycin is not stable in gastric fluid due to its acid-labile nature, which leads to its degradation in the acidic environment of the stomach.

Question 6

&#8230;&#8230;&#8230;types of drugs are absorbed by pore transport mechanism.&#10;A)Macromolecules&#10;B)Ionic drugs&#10;C)Drugs with molecular weight 100-400&#10;D)Water soluble drugs of molecular weight less than 100

Accepted Answer

Pore transport mechanism primarily facilitates the absorption of small, water-soluble drugs with a molecular weight less than 100. This is because the pores or channels in biological membranes are typically only large enough to allow the passage of small molecules.

Question 7

Area in which the carrier system is most dense is called as&#8230;&#8230;&#8230;&#8230;..&#10;A)Therapeutic window&#10;B)Absorption index&#10;C)Therapeutic index&#10;D)Absorption window

Accepted Answer

The term "absorption window" refers to the part of the gastrointestinal tract where a drug's absorption is most efficient, indicating the area where the carrier system is most dense for that drug.

Question 8

Which of the following is carrier mediated transport system&#10;A)passive diffusion&#10;B)active transport&#10;C)pore transport&#10;D)none of the above

Accepted Answer

Active transport is a carrier-mediated transport system that moves substances across a cell membrane against their concentration gradient, requiring energy in the form of ATP.

Question 9

Absorption of poorly soluble drug is&#10;A)diffusion rate limited&#10;B)dissolution rate limited&#10;C)both (a) & (b)&#10;D)none of the above

Accepted Answer

Poorly soluble drugs are typically dissolution rate limited because their rate of dissolution in the gastrointestinal fluids is slower than their rate of diffusion across the intestinal membrane.

Question 10

Which of the following process drug moves from site of administration to systemic circulation?&#10;A)excretion&#10;B)absorption&#10;C)distribution&#10;D)metabolism

Accepted Answer

Absorption is the process through which drugs move from the site of administration into the systemic circulation, allowing them to exert their effects on the body.

Question 11

Based on Henderson-Hasselbalch equation, at what pH value a weak acid would be 99.9% ionized?&#10;A)At pH equivalent to pKa - 3&#10;B)At pH equivalent to pKa + 3&#10;C)At pH equivalent to pKa - 1&#10;D)At pH equivalent to pKa + 1

Accepted Answer

The answer of Based on Henderson-Hasselbalch equation, at what pH...

Question 12

In passive diffusion, the transport of drugs takes place from a region of &#8230;&#8230;&#8230;&#8230;&#8230;concentration to a &#8230;&#8230;&#8230;&#8230;&#8230;..concentration.&#10;A)Lower, Higher&#10;B)Higher, Lower&#10;C)Both (a) and (b)&#10;D)none of the above

Accepted Answer

The answer of In passive diffusion, the transport of drugs...

Question 13

Which is the major process of absorption for more than 90% of drugs?&#10;A)Facilitated diffusion&#10;B)Active transport&#10;C)Endocytosis&#10;D)Passive diffusion

Accepted Answer

The answer of Which is the major process of absorption...

Question 14

What is the driving force for Passive Diffusion?&#10;A)Concentration gradient only&#10;B)Electrochemical gradient only&#10;C)Charge equilibration and concentration gradient&#10;D)Concentration and Electrochemical gradient both

Accepted Answer

The answer of What is the driving force for Passive...

Question 15

Which kind of molecules cannot pass through a pore transport?&#10;A)Low Molecular weight molecules&#10;B)Water-soluble drugs&#10;C)Molecules up to 400 Dalton&#10;D)Molecules greater than 400 Dalton

Accepted Answer

The answer of Which kind of molecules cannot pass through...

Question 16

What is the driving force of Pore Transport?&#10;A)Hydrostatic pressure&#10;B)Concertation Gradient&#10;C)Electrochemical gradient&#10;D)Charge equilibration

Accepted Answer

The answer of What is the driving force of Pore...

Question 17

What will be the best definition for &#34;carrier&#34;?&#10;A)Nonpolar drugs can be transported through carrier-mediated transport&#10;B)Carrier binds reversibly and no covalently with the molecules&#10;C)It discharges the molecules and gets destroyed itself&#10;D)The carrier is a protein

Accepted Answer

The answer of What will be the best definition for...

Question 18

What is the major difference between Facilitated diffusion and Passive diffusion?&#10;A)Carrier-mediated transport&#10;B)Downhill transport&#10;C)Energy is used&#10;D)Inhibition by metabolic poisons

Accepted Answer

The answer of What is the major difference between Facilitated...

Question 19

What influences the permeation of drugs in an Ionic or Electrochemical diffusion?&#10;A)Charge on the membrane&#10;B)Charge on the particle&#10;C)Concentration gradient&#10;D)Equilibration of charge

Accepted Answer

The answer of What influences the permeation of drugs in...

Question 20

Which kind of drugs are absorbed through endocytosis?&#10;A)Molecular weight ranging 100-400Dalton&#10;B)Water-soluble drugs&#10;C)Macromolecular drugs or drugs as oily droplets&#10;D)Polar drugs

Accepted Answer

The answer of Which kind of drugs are absorbed through...

Question 21

Which drugs are absorbed through pore transport?&#10;A)High lipophilicity&#10;B)Water-soluble drugs of molecular weight less than 100 Dalton&#10;C)Oily droplets&#10;D)Affinity for carriers

Accepted Answer

The answer of Which drugs are absorbed through pore transport?&#10;A)High...

Question 22

Which types of drugs get absorbed by ion-pair transport?&#10;A)High lipophilicity&#10;B)Oily droplets&#10;C)Affinity for carriers&#10;D)Drugs that ionize at all pH conditions

Accepted Answer

The answer of Which types of drugs get absorbed by...

Question 23

Which of these absorption methods involves engulfing of the extracellular drug?&#10;A)Endocytosis&#10;B)Passive diffusion&#10;C)Facilitated diffusion&#10;D)Ion-Pair tr

Accepted Answer

The answer of Which of these absorption methods involves engulfing...

Question 24

Which is the other name of &#34;cell eating&#34;?&#10;A)Transcytosis&#10;B)Phagocytosis&#10;C)Pinocytosis&#10;D)Endocytosis

Accepted Answer

The answer of Which is the other name of &#34;cell...

Question 25

Transfer of an endocytic vesicle from one extracellular compartment to another is known as&#10;A)Phagocytosis&#10;B)Transcytosis&#10;C)Pinocytosis&#10;D)Endocytosis

Accepted Answer

The answer of Transfer of an endocytic vesicle from one...

Deck 3: Drug Absorption Mechanisms and Processes