Deck 5: Pharmaceutical Formulation and Dosage

Question 1

For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems?

A)0.9%
B)1%
C)2%
D)0.11%

Answer 1

1%

Question 2

The total solid surface area of any particle is known as ___________

A)Absolute surface area
B)Effective surface area
C)Total surface area
D)Surface area

Answer 2

Absolute surface area

Question 3

Particle size and surface area of a drug are directly related to each other.

A)True
B)False
C)none
D)all

Answer 3

False

Question 4

Absolute surface area is proportional to the dissolution rate of a drug.

A)True
B)False
C)none
D)all

Question 5

In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement?

A)The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability
B)The particles reaggregate to form larger particles due to their high surface free energy
C)Extreme reduction in the particle size imparts surface charges that may prevent wetting
D)Extreme reduction in the size brings the hydrophobic amino acids to the surface

Question 6

How the absolute surface area of hydrophobic drugs can be converted to their effective surface area?

A)Use of surfactant
B)Use of Hydrophobic diluents
C)Use of surfactant and hydrophilic diluents
D)No need of doing micronization

Question 7

Which one of these is not an example of hydrophilic diluents?

A)PVC
B)Dextrose
C)PVP
D)PEG

Question 8

The solvate can exist in different crystalline forms called as _________

A)Solvates
B)Pseudopolymorphs
C)Pseudopolymorphism
D)Hydrate

Question 9

Which form of a drug has greater solubility?

A)Anhydrous
B)Hydrate
C)Crystallised
D)Monohydrate

Question 10

Which one will be the easiest approach to enhance the solubility and dissolution of any drug?

A)Micronize the drug
B)Convert drug into their anhydrous form
C)Convert drug into their hydrous form
D)Convert drug into their salt form

Question 11

What is pH?

A)-ve log of H+ concentration
B)+ve log of H+ concentration
C)Log of H+ concentration
D)H+ concentration

Question 12

Which one of these is not an advantage of buffered aspirin tablets?

A)Enhanced bioavailability
B)Reduced gastric irritation
C)Increased stability
D)Increased ulcerogenic tendency

Question 13

Larger the size of the counterion, greater the solubility.

A)True
B)False
C)none
D)all

Question 14

Which of the following will be the slowest step in tablet drug absorption?

A)Tablet disintegration to granules
B)Granules disintegration to fine particles
C)Fine particles dissolution
D)Dissolution absorbed into the blood

Question 15

Aging of dosage form affects drug release.

A)True
B)False
C)none
D)all

Question 16

Which form of the drug has the highest bioavailability?

A)Coated tablets
B)Solutions
C)Tablets
D)Emulsions

Question 17

Why emulsion dosage form for lipophilic drug proved better?

A)Easy manufacturing
B)The higher stability of the drug in emulsion form
C)Presented a large surface area of oil to the GIT for the absorption of the drug
D)Fast clearance from the plasma

Question 18

Which is the major rate-limiting step in the absorption of a drug from suspension dosage?

A)Tablet disintegration to granules
B)Granules disintegration to fine particles
C)Fine particles dissolution
D)Dissolution absorbed into the blood

Question 19

Which coating is thin and dissolves rapidly?

A)Sugar coating
B)Film coating
C)Enteric coating
D)Sealing coating

Question 20

Which option describes the function of the enteric coated drug?

A)Tough dissolves slowly
B)Thin dissolves completely
C)Dissolves only in alkaline pH of the intestine
D)Shellac coating

Question 21

Hydrophobic drug with fine particle size in capsule results in a decreasing porosity of powder bed.

A)True
B)False
C)none
D)all

Question 22

Viscous fluids and oils are administered in hard gelatin capsules.

A)True
B)False
C)none
D)all

Question 23

From the below options which will be the most widely used form of dosage?

A)Emulsion
B)Solutions
C)Tablets
D)Powders

Question 24

In cell membrane the hydrocarbon chains for hydrophilic phase and the polar heads form hydrophobic phase.

A)True
B)False
C)none
D)all

Question 25

Proteins interact with which part of the cell membrane?

A)Hydrophobic tail
B)Polar head
C)Non polar head
D)Hydrophilic tail