Deck 9: Pharmacokinetics and Drug Distribution: Understanding Absorption and Transport in the Body

Question 1

Which of the following drug is not intended for pulmonary administration?

A)Bronchodilators
B)Antiallergics
C)NSAIDs
D)Anti-inflammatory steroids

Answer 1

NSAIDs

Question 2

A drug in the concentrated injection is absorbed faster.

A)True
B)False
C)none
D)all

Answer 2

True

Question 3

Intramuscular drug absorption is faster than intravascular.

A)True
B)False
C)none
D)all

Answer 3

False

Question 4

Several factors such as the thickness of stratum corneum, presence of hair follicles, trauma, hydration of the skin, Grooming, exposure to chemicals determine the passive absorption of drugs from the surface of the skin to below.

A)True
B)False
C)none
D)all

Question 5

Which process involve alteration of drug distribution

A)Competitive binding
B)Reduced plasma protein level
C)Both
D)None

Question 6

If drug have very small volume of distribution it is likely that the drug

A)Has short biological half life
B)Does not accumulate in various tissue and organ
C)Not bioavailable
D)will not be effective

Question 7

If distribution of drug is slower than process of biotransformation and elimination

A)It will cause high blood level of drug
B)It will cause low blood level of drug
C)Cause failure to attain diffusion equilibrium
D)None of the above

Question 8

If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the given statement is true?

A)Apparent volume of distribution of drug X decrease
B)Free concentration of drug X in blood will be increase
C)Apparent volume of distribution of drug Y decrease
D)Toxicity of drug Y increase

Question 9

The distribution of drugs into the central nervous system (brain) usually depends on:

A)Aqueous diffusion
B)Lipid diffusion
C)Active transport
D)Facilitated tr

Question 10

Which of the following is most likely to be associated with a high apparent volume of distribution

A)High hepatic extraction ratio
B)Penetration across the blood:brain and blood:testes barriers
C)Extensive binding to plasma protein
D)Extensive binding to tissue constituents

Question 11

The Initial distribution of drug into the tissue is determined chiefly by

A)Rate of blood flow to tissue
B)Plasma protein binding of drug
C)Affinity for tissue
D)Gastric emptying time

Question 12

Transfer of drug from plasma to tissue depends on

A)Weight of tissue
B)Blood perfusion rate of tissue
C)Size of tissue
D)All of the above

Question 13

A hydrophilic medicinal agent has

A)Low ability to penetrate through the cell membrane lipids
B)Easy permeation through the blood-brain barrier
C)Penetrate through membranes by means of endocytosis
D)High reabsorption in renal tubules

Question 14

Biological barriers include all except:

A)Renal tubules
B)Cell membranes
C)Capillary walls
D)Placenta

Question 15

Blood Brain Barrier is maximum permeable to

A)Na+
B)C02
C)Cl
D)K+

Question 16

If a CNS drug is extensively ionized at pH of blood it will

A)Penetrate the blood brain barrier slowly
B)Penetrate the blood brain barrier rapidly
C)Not penetrate blood brain barrier
D)Be eliminated slowly

Question 17

The rate of drug transport across a cell membrane by lipid diffusion depends on all of the following except

A)Drug size (diffusion constant)
B)Surface area of absorption
C)Lipid partition coefficient
D)Density of tr

Question 18

The formula to calculate half life (t1/2) is

A)0.693 *Vd / C1
B)0.693 *Cl / Vd
C)0.693 / Cl * Vd
D)0.693 / Cl

Question 19

The procedure of transporting a drug from the bloodstream to tissues is called as

A)Absorption
B)Dissolution
C)Distribution
D)Elimination

Question 20

…………..it represents the degree to which a drug is distributed in body tissue rather than

A)Volume of distribution (YD)
B)Effect of distribution
C)Area of distribution
D)None of the above

Question 21

It is defined as the distribution of a drug between plasma and the rest of the body after oral or parenteral dosing.

A)Volume of distribution (VD)
B)Apparent volume of drug distribution
C)Phagocytosis
D)None of the above

Question 22

The drugs having molecular size …………..easily cross capillary membrane.

A)<500-600d
B)< 100-200 d
C)<300-600d
D)<90M600d

Question 23

The concentration of drug in blood or plasma will be comparatively in the GI tract.

A)High
B)Low
C)Very High
D)Very Low

Question 24

Fat is act as reservoir for……………………… Drugs

A)Highly water soluble
B)Lower lipid soluble
C)Highly lipid soluble.
D)Lower lipid soluble.

Question 25

Displacement is significant when, the displaced drug is more than protein bound.

A)50%
B)95%
C)10%
D)1%