Deck 12: Pharmacokinetics and Drug Distribution: Understanding Tissue-Drug Binding and Accumulation

Question 1

In meningitis and encephalitis polar antibiotics gain access to BBB which don't happen to a healthy person.

A)True
B)False
C)none
D)all

Answer 1

True

Question 2

What reasons make tissue-drug binding important for drug distribution?

A)Increases the volume of distribution of drugs and results in localization of drug at a specific site
B)Increases the volume of distribution of drugs
C)Results in localization of drugs at a tissue specific site
D)Increases in absorption from the tissue due to concentration increasing

Answer 2

Increases the volume of distribution of drugs and results in localization of drug at a specific site

Question 3

Following is the order in decreasing order of drug binding to the extravascular tissue. Which one is the correct order?

A)Liver > kidney > muscle > lung
B)Liver > muscle > lung > kidney
C)Liver > muscle > kidney > lung
D)Liver > kidney > lung > muscle

Answer 3

Liver > kidney > lung > muscle

Question 4

What is the relation between halogenated hydrocarbon and liver?

A)Halogenated hydrocarbon is a drug for liver problems
B)Halogenated hydrocarbon is nutrition for liver
C)Halogenated hydrocarbon causes hepatotoxicity
D)Halogenated hydrocarbon forms the bile juices in liver

Question 5

Which drugs accumulate in liver?

A)Acidic drugs like imipramine
B)Basic drugs like imipramine
C)Halogenated hydrocarbons
D)Chloroquinine

Question 6

Which metals get accumulated in kidney?

A)Mercury, cadmium, lead
B)Mercury, cadmium, iron
C)Mercury, lanthanum, lead
D)Mercury, cadmium, fluoride ions

Question 7

Which of the following drugs accumulate in skin?

A)Acidic drugs like imipramine
B)Basic drugs like imipramine
C)Halogenated hydrocarbons
D)Chloroquine

Question 8

Which of the following drugs are responsible for retinopathy?

A)Acidic drugs like imipramine
B)Basic drugs like imipramine
C)Halogenated hydrocarbons
D)Chloroquinine

Question 9

Which drugs deposit in hair shafts?

A)Arsenicals
B)Tetracycline
C)Halogenated hydrocarbons
D)Lipophilic drug

Question 10

Which drug causes brown yellow discoloration of infant's teeth?

A)Arsenicals
B)Tetracycline
C)Halogenated hydrocarbons
D)Lipophilic drug

Question 11

Which drug accumulate in adipose tissue?

A)Arsenicals
B)Tetracycline
C)Halogenated hydrocarbons
D)Lipophilic drug

Question 12

Which drugs results in distortion of double stranded DNA structure?

A)Arsenicals
B)Quinacrine
C)Halogenated hydrocarbons
D)Lipophilic drug

Question 13

In equation X=Vd C, what does Vd denotes?

A)Density
B)Volume of blood
C)Volume of body
D)The volume of the body fluid in which the drug is getting dissolved

Question 14

The amount of drug in the body is directly proportional to the concentration of the drug in plasma.

A)True
B)False
C)none
D)all

Question 15

The body water has 3 distinct compartments. Which one of these is not one of the compartments?

A)Vascular fluid
B)Intracellular fluid
C)Extracellular fluid
D)Between the tissue layers

Question 16

How can you determine the extracellular fluid volume?

A)Evans blue
B)Na+
C)D20
D)Tritiated water

Question 17

How a patient's plasma volume can be determined?

A)Evans blue
B)Na+
C)D20
D)Tritiated water

Question 18

The total body water volume can be determined by using high molecular weight dyes.

A)True
B)False
C)none
D)all

Question 19

How will you determine the intracellular fluid volume?

A)Evans blue
B)Na+
C)Difference between total body water and ECF volume
D)Tritiated water

Question 20

What will be the apparent volume of distribution of warfarin?

A)The apparent volume of distribution is less than the true volume of distribution
B)The apparent volume of distribution is more than the true volume of distribution
C)The apparent volume of distribution is equal to the true volume of distribution
D)Warfarin is not a medicine

Question 21

What will bet the apparent volume of distribution of drugs which binds selectively to extravascular tissues?

A)The apparent volume of distribution is less than the true volume of distribution
B)The apparent volume of distribution is more than the true volume of distribution
C)The apparent volume of distribution is equal to the true volume of distribution
D)The apparent volume of distribution is equal to the volume of extravascular tissues

Question 22

Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.

A)True
B)False
C)none
D)all

Question 23

Which one of the following bonds is not generally a bond through which a drug will bind in our body?

A)Hydrogen bond
B)Hydrophobic bond
C)Ionic bond
D)Covalent bond

Question 24

Binding of drugs falls into 2 components those are _______________

A)Binding of drugs to blood components and to extravascular tissue
B)Binding of drugs to blood components and to other cells
C)Binding of drugs to cells and blood cells
D)Binding of drugs to blood components to bones and cells

Question 25

Which one of the following is the correct order of the drugs binding to various plasma protein?

A)Albumin > alpha-1 acid glycoprotein > globulins > lipoproteins
B)Albumin > globulins > lipoproteins > alpha-1 acid glycoprotein
C)Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins
D)Albumin > lipoproteins > globulins > alpha-1 acid glycoprotein