Question 1

Which of the following drug bind to ?1 globulin?&#10;A)Steroids&#10;B)Ferrous ion&#10;C)Carotenoid&#10;D)Vitamin D

Accepted Answer

Steroids bind to ?1 globulin, which is also known as transcortin or corticosteroid-binding globulin (CBG).

Question 2

What is interaction of phenobarbitone and warfarin?&#10;A)Displacement of warfarin from binding site&#10;B)Decreased absorption of warfarin&#10;C)Increase metabolism of warfarin&#10;D)Decreased metabolism of warfarin

Accepted Answer

Phenobarbitone induces the hepatic enzymes responsible for the metabolism of warfarin, leading to decreased plasma concentrations of warfarin.

Question 3

Which process involves alteration of drug distribution?&#10;A)Competitive binding&#10;B)Reduced plasma protein level&#10;C)Both&#10;D)None

Accepted Answer

Both competitive binding and reduced plasma protein levels can alter the distribution of a drug within the body. Competitive binding can change how drugs are distributed by affecting their binding to plasma proteins, leading to more free drug available for distribution. Similarly, reduced plasma protein levels decrease the binding sites available for drugs, potentially increasing the concentration of free drug in the circulation and altering its distribution.

Question 4

Two most common protein involved in plasma protein binding are&#10;A)Globulin and plasmin&#10;B)Albumin and globulin&#10;C)Fibrin and globulin&#10;D)Plasmin and fibrin

Accepted Answer

Albumin and globulin are the two most common proteins involved in plasma protein binding. Albumin, being the most abundant protein in plasma, plays a significant role in binding various substances, including drugs, while globulins are involved in immune functions and also bind to certain hormones and lipids.

Question 5

All of the following displace imipramine from protein binding site except&#10;A)Aspirin&#10;B)Phenytoin&#10;C)Ethosuximide&#10;D)Phenylbutazone

Accepted Answer

Ethosuximide does not significantly displace imipramine from protein binding sites, unlike aspirin, phenytoin, and phenylbutazone, which can displace imipramine, leading to increased levels of free imipramine in the plasma.

Question 6

The drugs which are most affected in pregnancy are those having&#10;A)Low protein binding and high Vd&#10;B)High protein binding and low Vd&#10;C)High protein binding and high Vd&#10;D)Low protein binding and low Vd

Accepted Answer

Drugs with high protein binding and low volume of distribution (Vd) are most affected in pregnancy because the physiological changes during pregnancy, such as increased plasma volume and altered levels of plasma proteins, can significantly impact the pharmacokinetics of these drugs. High protein binding drugs are more likely to be displaced from their binding sites due to the increased levels of certain plasma proteins or competition from other substances, leading to higher free drug concentrations. Low Vd means the drug is less distributed into tissues, making it more susceptible to changes in plasma protein levels.

Question 7

Most of drugs will bind with which of plasma protein&#10;A)Albumin&#10;B)Globulin&#10;C)Histone&#10;D)Glycoprotein

Accepted Answer

Albumin is the most common plasma protein that drugs bind to due to its abundance in the bloodstream and its ability to bind a wide variety of drugs.

Question 8

Which of the following is not highly protein bound drug&#10;A)Barbiturates&#10;B)Phenylbutazone&#10;C)Salicylates&#10;D)Aspirin

Accepted Answer

Aspirin is not highly protein-bound compared to the other options listed. It has a moderate protein binding rate, whereas barbiturates, phenylbutazone, and salicylates are known to be highly protein-bound.

Question 9

Blood plasma belongs to&#10;A)Interstitial fluid&#10;B)Intracellular fluid&#10;C)Extracellular fluid&#10;D)All of the above

Accepted Answer

The answer of Blood plasma belongs to&#10;A)Interstitial fluid&#10;B)Intracellular fluid&#10;C)Extracellular fluid&#10;D)All...

Question 10

Drug elimination involves....... (ADME are steps of pharmacokinetics)&#10;A)ADME&#10;B)DME&#10;C)ME&#10;D)E only

Accepted Answer

Drug elimination specifically refers to the "Metabolism" (M) and "Excretion" (E) phases of pharmacokinetics.

Question 11

Filtration fraction is&#10;A)Fraction of plasma passing through the kidney which is filtered at glomerulus&#10;B)Ratio of iulin clearance to PAH clearance&#10;C)Ration of CFR to RPF&#10;D)None of them

Accepted Answer

The answer of Filtration fraction is&#10;A)Fraction of plasma passing through...

Question 12

What is the half life of a drug with a volume of distribution of 100U70kg and a clearance of 7t/hr/70kg&#10;A)15 hours&#10;B)10 hours&#10;C)13.5 hours&#10;D)5 hours

Accepted Answer

The answer of What is the half life of a...

Question 13

A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate of blood flow to the liver would be&#10;A)60 milliliters/min&#10;B)120 milliliters/min&#10;C)650 milliliters/min&#10;D)1500 milliliters/min

Accepted Answer

The answer of A Normal sized adult having hepatic clearance...

Question 14

Which process involves alteration in drug excretion?&#10;A)Increased fluid flow&#10;B)Changes in urinary pH&#10;C)Both&#10;D)None

Accepted Answer

The answer of Which process involves alteration in drug excretion?&#10;A)Increased...

Question 15

Which of the following is not a step of renal excretion?&#10;A)Glomerular filtration&#10;B)Tubular filtration&#10;C)Tubular reabsorption&#10;D)Secretion

Accepted Answer

The answer of Which of the following is not a...

Question 16

Renal clearance is expressed as&#10;A)Rate of urinary excretion / Plasma drug concentration&#10;B)Elimination Rate / Plasma drug concentration&#10;C)Rate of urinary excretion / Elimination Rate&#10;D)Elimination Rate

Accepted Answer

The answer of Renal clearance is expressed as&#10;A)Rate of urinary...

Question 17

Glomerular filtration rate would be increased by&#10;A)constriction of the afferent arteriole&#10;B)decrease in afferent arteriolar pressure&#10;C)compression of the renal capsule&#10;D)decrease in the concentration of plasma protein

Accepted Answer

The answer of Glomerular filtration rate would be increased by&#10;A)constriction...

Question 18

The volume of plasma needed each minute to supply a substance at the rate at which it is excreted in the urine is known as the&#10;A)diffusion constant of the substance&#10;B)clearance of the substance&#10;C)extraction ratio of the substance&#10;D)filtration rate of the substance

Accepted Answer

The answer of The volume of plasma needed each minute...

Question 19

Nephron is functional unit of&#8230;&#8230;&#8230;&#8230;..&#10;A)Kidney&#10;B)Heart&#10;C)Lung&#10;D)Liver

Accepted Answer

The answer of Nephron is functional unit of&#8230;&#8230;&#8230;&#8230;..&#10;A)Kidney&#10;B)Heart&#10;C)Lung&#10;D)Liver...

Question 20

Hepatic extraction ratio of 0.60 indicates that&#10;A)40% drug is left after extraction by the liver&#10;B)60% drug is left after extraction by the liver&#10;C)Only 0.6% drug is removed by the liver&#10;D)None of the above

Accepted Answer

The answer of Hepatic extraction ratio of 0.60 indicates that&#10;A)40%...

Question 21

First pass metabolism occurs in:&#10;A)Liver&#10;B)In lungs&#10;C)In kidneys&#10;D)In pancreas

Accepted Answer

The answer of First pass metabolism occurs in:&#10;A)Liver&#10;B)In lungs&#10;C)In kidneys&#10;D)In...

Question 22

The term &#34;biotransformation&#34; includes the following.&#10;A)Accumulation of substances in a fat tissue&#10;B)Process of physicochemical and biochemical alteration of a drug in the body&#10;C)Binding of substances with plasma proteins&#10;D)Accumulation of substances in a tissue

Accepted Answer

The answer of The term &#34;biotransformation&#34; includes the following.&#10;A)Accumulation of...

Question 23

For the calculation of the volume of distribution (Vd) one take into account:&#10;A)Concentration of a substance in urine&#10;B)Concentration of substance in plasma&#10;C)A daily dose of drug&#10;D)Therapeutic width of drug action

Accepted Answer

The answer of For the calculation of the volume of...

Question 24

Biotransformation of a medicinal substance results in:&#10;A)Slower urinary excretion&#10;B)Faster urinary excretion&#10;C)Higher binding to membranes&#10;D)Easier distribution in organism

Accepted Answer

The answer of Biotransformation of a medicinal substance results in:&#10;A)Slower...

Deck 14: Pharmacokinetics and Drug Elimination