Deck 21: Pharmacokinetic and Drug Administration Concepts

Question 1

……….. is a mathematical concept which describes a space in the body which a drug appears to occupy.

A)Order of reaction
B)Compartment
C)Distribution
D)Elimination

Answer 1

Compartment

Question 2

………………..is the manner in which a drug is taken.

A)Dosage regimen
B)Dosage volume
C)Dosage loading
D)None of the above

Answer 2

Dosage regimen

Question 3

…………………it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.

A)Accumulation Index
B)Apparent volume of drug distribution
C)Accumulation factor
D)None of the above

Answer 3

Accumulation Index

Question 4

…............ is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose.

A)Primary Dose
B)Initial Dose
C)Loading dose
D)None of the above

Question 5

The compartment models provide visual representation of various rate processes involved in drug disposition. Given statement is:

A)False
B)True
C)Cannot say
D)None of the above

Question 6

...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid and uniform drug distribution.

A)Central compartment
B)Peripheral compartment
C)both of the above
D)None of the above

Question 7

……………composed of groups of tissues with lower blood perfusion and different affinity the drug with slow drug distribution.

A)Central compartment
B)Peripheral compartment
C)Both of the above
D)None of the above

Question 8

A multicompartment model assumes that all transfer rate processes for the passage of drug into or out of individual compartments are…………….. processes.

A)First-order
B)Second order
C)Pseudo order
D)None of the above

Question 9

The multicompartment models are intended to provide…………….

A)Therapeutic activity of the drug
B)Achieve maximum efficacy
C)Both of the above
D)None of the above

Question 10

The biological half-life of drug:

A)is a constant physical property of the drug
B)is a constant chemical property of the drug
C)may be increased in patients with impaired renal failure
D)may be decreased in patients by giving the drug by rapid I.V. injection

Question 11

The half life of a drug eliminated by first order elimination kinetics will be longer in individuals who have an:

A)increased volume of distribution or increased clearance
B)increased volume of distribution or decreased clearance
C)decreased volume of distribution or increased clearance
D)decreased volume of distribution or decreased clearance

Question 12

Half life (t1/2) is the time required to:

A)change the amount of a drug in plasma by half during elimination
B)metabolize a half of an introduced drug into the active metabolite
C)absorb a half of an introduced drug
D)bind a half of an introduced drug to plasma proteins

Question 13

Half life (t1/2) does not depend on:

A)biotransformation
B)time of drug absorption
C)concentration of a drug in plasma
D)rate of drug elimination

Question 14

Elimination rate constant (Kelim) is defined by the following parameter:

A)rate of absorption
B)maximal concentration of a substance in plasma
C)highest single dose
D)half life (t1/2)

Question 15

Systemic clearance (Cl) is related with:

A)only the concentration of substances in plasma
B)only the elimination rate constant
C)volume of distribution, half life and elimination rate constant
D)bioavailability and half life

Question 16

Biological Half life equation for first order process is

A)t1/2 = a/2K
B)t1/2 = 0.693/K
C). t1/2 = 1/aK
D). t1/2 = 3/2 K

Question 17

The area under the serum concentration time curve of the drug represents:

A)the biological half life of the drug
B)the amount of drug in the original dosage form
C)The amount of drug absorbed
D)The amount of drug excreted in the urine

Question 18

Drug having ……..half-lives take a very short time to achieve plateau concentration.

A)shorter
B)longer
C)intermediate
D)none of the above

Question 19

The primary pharmacokinetic parameter clearance can be calculated by

A)Cl = KV
B)Cl = Dose/AUC
C)Cl = (dA/dt)/C
D)all of the above

Question 20

………..change in drug kinetics is known as chronokinetics.

A)Time-dependent
B)Dose-dependent
C)Both (a) & (b)
D)None of the above

Question 21

Constant rate infusion prevents………..in blood levels.

A)fluctuations
B)peak maximum
C)valley minimum
D)all of the above

Question 22

Constant rate infusion is……..

A)prevents fluctuations
B)useful when drug has narrow TI
C)Both (a) & (b)
D)none of the above

Question 23

Concentration of drug at peak is known as …………drug concentration.

A)maximum
B)minimum
C)lower
D)none of the above

Question 24

In one compartment open model, the term open indicates input and output is:

A)unidirectional
B)bidirectional
C)non-directional
D)none of the above

Question 25

The mathematical relationship between plasma drug concentration and pharmacological response is called as………..

A)PK modeling
B)PD modeling
C)PK-PD modeling
D)None of the above