Deck 23: Pharmacokinetics and Haemodialysis

Question 1

Which creatinine clearance value shows severe renal failure?

A)120-130 ml/min
B)20-50 ml/min
C)Below 10 ml/min
D)70-80 ml/min

Answer 1

Below 10 ml/min

Question 2

Drugs in patients with renal impairment have same pharmacokinetic profile as in a person without renal failure.

A)True
B)False
C)none
D)all

Answer 2

False

Question 3

Which kind of membrane is used in haemodialysis?

A)Artificial Semipermeable membrane
B)Permeable membrane
C)Natural semipermeable membrane of the peritoneal cavity
D)Artificial permeable membrane

Answer 3

Artificial Semipermeable membrane

Question 4

Which kind of membrane is used in haemodialysis?

A)Artificial Semipermeable membrane
B)Permeable membrane
C)Natural semipermeable membrane of peritoneal cavity
D)Artificial permeable membrane

Question 5

Which of the following will not be a factor governing the removal of substances through dialysis?

A)Molecular weight
B)Water solubility
C)Disintegration time
D)Protein binding

Question 6

Haemodialysis is also known as extracorporeal dialysis.

A)True
B)False
C)none
D)all

Question 7

Which of the following is not a mechanism for pharmacokinetic analysis?

A)Compartment analysis
B)Non compartment analysis
C)Physiologic modeling
D)Human model

Question 8

In which of the following models the body is considered to be composed of several compartments?

A)Compartment model
B)Noncompartment model
C)Physiologic model
D)Human model

Question 9

In which of the model peripheral compartments are connected to a central compartment?

A)Compartment model
B)Caternary model
C)Physiologic model
D)Mammillary model

Question 10

Which organs will make up the peripheral compartment?

A)Lungs
B)Liver
C)Kidneys
D)Pancreas

Question 11

In which model compartments are joined in series?

A)Compartment model
B)Caternary model
C)Physiologic model
D)Mammillary model

Question 12

Which of the following is not a characteristic of the caternary compartment model?

A)It gives a visual representation of various rate processes in drug disposition
B)It shows how many rate constants are necessary
C)Compartments and parameters bear a relationship with physiologic functions
D)Useful in predicting drug

Question 13

In noncompartmental analysis, Mean residence time is equal to _____________

A)The area under the first moment curve/area under the zero moment curve
B)The area under the zero moment's curve/area under the first moment curve
C)1 / Area under the first-moment curve
D)1/ Area under the zero moment curve

Question 14

Which pharmacokinetic model is drawn on the basis of anatomic and physiologic data?

A)Compartment model
B)Caternary model
C)Physiologic model
D)Mammillary model

Question 15

Which of the following will be a disadvantage for the physiologic model?

A)Prediction of drug concentration in various body regions
B)Correlation of data in several animal species
C)Obtaining experimental data for each of the organs
D)The model gives an exact description of the drug concentration-time profile for any organ

Question 16

Which model is also known as membrane permeation rate limited?

A)Physiologic model
B)Compartment model
C)Noncompartment model
D)Mammillary model

Question 17

What does the word "open" mean in the one compartment open model?

A)The drug easily enters
B)The drug readily mixes with the blood
C)Unidirectional input and output
D)Easy absorption

Question 18

How much time does an intravenously administered drug take to complete a complete circulation?

A)5-8 min
B)7-10 min
C)1-3 min
D)1 min

Question 19

In the equation log C = log Co - KEt/2.303, what does Co stand for _______

A)Plasma drug concentration after 60 min of i.v. injection
B)Plasma drug concentration after 15 min of i.v. injection
C)Plasma drug concentration after 30 min of i.v. injection
D)Plasma drug concentration immediately after i.v. injection.

Question 20

What is meant by elimination half-life?

A)Time take for half of the amount of drug to get completely eliminated from only the organs
B)Time take for half of the amount of drug to get completely eliminated from only blood
C)Time take for half of the amount of drug to get completely eliminated from only plasma
D)Time take for half of the amount of drug to get completely eliminated from the body as well as plasma

Question 21

What is the equation to find out the apparent volume of distribution?

A)Amount of drug in the body/plasma drug concentration
B)Plasma drug concentration/amount of drug in the body
C)1 / plasma drug concentration
D)1 / Amount of drug in the body

Question 22

The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?

A)625 mg/ml
B)625 l
C)625 ml
D)0.0016 mg/ml

Question 23

To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?

A)1080 ml
B)1080 g
C)1080 mg
D)1g/ml

Question 24

What is the equation to find out hepatic clearance?

A)Plasma drug concentration/rate of elimination by the kidney
B)Rate of elimination by kidney/plasma drug concentration
C)1 / rate of elimination by the kidney
D)1 / plasma drug concentration

Question 25

Which organs comprise the central compartment in a two compartment model?

A)Muscles
B)Skin
C)Adipose
D)Liver