Deck 10: Antihypertensive Drugs

Question 1

A patient with a hypertensive emergency is given an intravenous infusion of a drug that dilates renal afferent and efferent arterioles and is rapidly metabolized with a half-life of 5 minutes. Which mechanism is responsible for the therapeutic effect of this drug?

A) activation of dopamine D1 receptors
B) activation of dopamine D2 receptors
C) blockade of α 1-adrenoceptors
D) activation of α 2-adrenoceptors
E) blockade of α 1- and β
1-adrenoceptors

Answer 1

activation of dopamine D1 receptors

Question 2

After several months of antihypertensive drug therapy, a patient develops a lupus erythematosus-like syndrome.
Which agent is most likely responsible for this adverse effect?

A) minoxidil
B) hydrochlorothiazide
C) captopril
D) verapamil
E) hydralazine

Answer 2

hydralazine

Question 3

Which antihypertensive drug is most likely to reduce vascular injury by inhibiting activation of growth factors that cause smooth muscle proliferation and hypertrophy?

A) clonidine
B) terazosin
C) atenolol
D) candesartan
E) nifedipine

Answer 3

candesartan

Question 4

Which enzyme serves as the receptor for aliskiren?

A) angiotensin-converting enzyme
B) renin
C) sodium-potassium adenosine triphosphatase
D) carbonic anhydrase
E) nitric oxide synthase

Question 5

Nitroprusside administration may lead to the accumulation of which toxic compound in the body?

A) formaldehyde
B) bromine
C) cyanide
D) nitrobenzene
E) superoxide