Deck 17: Drug Therapy for Gastrointestinal Disorders

Question 1

Which of the following neutralizes hydrochloric acid and raises gastric pH?

A) pancreatin
B) difenoxin with atropine
C) mannitol
D) aluminum hydroxide

Answer 1

aluminum hydroxide

Question 2

Calcium carbonate usually is avoided in the treatment of hyperacidity of the stomach because it causes which of the following adverse effects?

A) metabolic alkalosis
B) respiratory alkalosis
C) renal calculi
D) A and C

Answer 2

A and C

Question 3

Which of the following is an H₂-receptor antagonist?

A) ranitidine
B) magaldrate
C) esomeprazole
D) omeprazole

Answer 3

ranitidine

Question 4

Which of the following is a proton pump inhibitor?

A) nizatidine
B) cimetidine
C) furazolidone
D) lansoprazole

Question 5

Which of the following is the most potent H₂-receptor antagonist?

A) nizatidine
B) famotidine
C) ranitidine
D) cimetidine

Question 6

Which of the following is the most common adverse effect of antacids containing aluminum or calcium?

A) hypotension
B) insomnia
C) bone fracture
D) constipation

Question 7

Which of the following medications are contraindicated in long-term use for gastroesophageal reflux disease and duodenal ulcers?

A) proton pump inhibitors
B) H₂-receptor antagonists
C) antacids
D) antiflatulents

Question 8

All of the following antibiotics may be used for healing duodenal and gastric ulcers, except:

A) metronidazole (Flagyl )
B) amoxicillin (Amoxil )
C) rifampin (Rifadin )
D) clarithromycin (Biaxin )

Question 9

Pancreatic enzyme replacement therapy is contraindicated in which of the following conditions?

A) cystic fibrosis
B) esophageal strictures
C) pancreatectomy
D) pancreatic cancer

Question 10

Ursodiol is a naturally occurring bile acid that is made by the liver and secreted in bile. Which of the following is the mechanism of action of ursodiol?

A) It increases the production of bile in the small intestine.
B) It increases the movement of the bowels.
C) It blocks the liver enzyme that produces cholesterol.
D) It blocks the pancreatic enzyme that produces bile.

Question 11

Which of the following is used in the treatment of acid peptic disorders?

A) omeprazole
B) loperamide
C) pancrelipase
D) senna

Question 12

Which of the following agents are highly effective when combined with proton pump inhibitors and antibiotics for the eradication of H. pylori?

A) psyllium
B) mineral oil
C) sorbitol
D) bismuth compounds

Question 13

Which of the following antidiarrheals are the most effective drugs?

A) meperidine congeners
B) opioid narcotics
C) anticholinergics
D) all of the above are equally effective

Question 14

Which of the following is an adverse effect of antiflatulents?

A) itching
B) stomach pain
C) hyperuricemia
D) none of the above

Question 15

Which of the following is an example of fecal softeners?

A) docusate (Colace )
B) senna (Senokot )
C) bisacodyl (Dulcolax )
D) A and C

Question 16

Which of the following is an example of a lubricant?

A) glycerin
B) lactalose
C) mineral oil
D) polycarbophil

Question 17

Bulk-forming laxatives absorb water to soften the stool, and are known as natural or synthetic:

A) monosaccharides
B) disaccharides
C) polysaccharides
D) glycerides

Question 18

Mineral oil is a lubricant laxative that works in which of the following parts of the digestive system?

A) stomach
B) small intestine
C) large intestine
D) liver

Question 19

Which of the following H₂-receptor antagonists was approved first for clinical use?

A) ranitidine (Zantac )
B) cimetidine (Tagamet )
C) famotidine (Pepcid )
D) nizatidine (Axid )

Question 20

Which of the following is the generic name of Imodium ?

A) lomefloxacin
B) lomustine
C) loracarbef
D) loperamide

Question 21

The management of diarrhea depends on finding the underlying ____________________, and replacing water and ____________________ as needed.

Question 22

Antiflatulents are generally safe and have no ____________________.

Question 23

Pancreatic enzyme replacements include pancreatin and ____________________.

Question 24

Gastroesophageal reflux disease (GERD) involves the periodic flow of gastric contents into the ____________________.

Question 25

There is a relationship between Helicobacter infection and adenocarcinoma of the ____________________.

Question 26

The accessory organs of the digestive system include the salivary glands, liver, gallbladder, and __________.

Question 27

Mechanical digestion breaks large food particles into smaller pieces by __________.

Question 28

Peptic ulcer refers to a lesion located in the stomach or in the __________.

Question 29

Antacids neutralize hydrochloric acid and __________ gastric pH.

Question 30

An example of a prostaglandin E1 analog is __________.

Question 31

__________ was the first H₂-receptor antagonist approved for clinical use for peptic ulcer.

Question 32

Proton pump inhibitors are widely used in the __________-__________ therapy of duodenal and gastric ulcers.

Question 33

The main pancreatic enzymes include __________, amylase, chymotrypsin, and trypsin.

Question 34

Gallstones are usually formed by the combination of __________ and calcium compounds.

Question 35

Phazyme is an example of an __________.

Question 36

Stimulant laxatives work in the small and large intestine to stimulate bowel __________.

Question 37

Saline laxatives work by creating an osmotic effect that increases the water content and volume of the __________.

Question 38

Match the generic name with the trade name.

-rabeprazole

A) Prevacid
B) Aciphex
C) Nexium
D) Prilosec
E) Protonix
F) Dexilant

Question 39

An __________ is a drug that induces vomiting.

Question 40

Adsorbents are contraindicated in patients with suspected obstructive bowel lesion, and pseudomembranous __________.

Question 41

Match the generic name with the trade name.

-psyllium seed

A) Dulcolax
B) Emulsoil
C) Fleet Babylax
D) Mitrolan
E) Metamucil

Question 42

Match the generic name with the trade name.

-polycarbophil

A) Dulcolax
B) Emulsoil
C) Fleet Babylax
D) Mitrolan
E) Metamucil

Question 43

Match the generic name with the trade name.

-castor oil

A) Dulcolax
B) Emulsoil
C) Fleet Babylax
D) Mitrolan
E) Metamucil

Question 44

Match the generic name with the trade name.

-glycerin

A) Dulcolax
B) Emulsoil
C) Fleet Babylax
D) Mitrolan
E) Metamucil

Question 45

Match the generic name with the trade name.

-bisacodyl

A) Dulcolax
B) Emulsoil
C) Fleet Babylax
D) Mitrolan
E) Metamucil

Question 46

Match the generic name with the trade name.

-ranitidine

A) Pepcid
B) Axid
C) Zantac
D) Tagamet

Question 47

Match the generic name with the trade name.

-cimetidine

A) Pepcid
B) Axid
C) Zantac
D) Tagamet

Question 48

Match the generic name with the trade name.

-nizatidine

A) Pepcid
B) Axid
C) Zantac
D) Tagamet

Question 49

Match the generic name with the trade name.

-famotidine

A) Pepcid
B) Axid
C) Zantac
D) Tagamet

Question 50

Match the generic name with the trade name.

-dexlansoprazole

A) Prevacid
B) Aciphex
C) Nexium
D) Prilosec
E) Protonix
F) Dexilant

Question 51

Match the generic name with the trade name.

-omeprazole

A) Prevacid
B) Aciphex
C) Nexium
D) Prilosec
E) Protonix
F) Dexilant

Question 52

Match the generic name with the trade name.

-pantoprazole

A) Prevacid
B) Aciphex
C) Nexium
D) Prilosec
E) Protonix
F) Dexilant

Question 53

Match the generic name with the trade name.

-lansoprazole

A) Prevacid
B) Aciphex
C) Nexium
D) Prilosec
E) Protonix
F) Dexilant

Question 54

Match the generic name with the trade name.

-esomeprazole

A) Prevacid
B) Aciphex
C) Nexium
D) Prilosec
E) Protonix
F) Dexilant