Deck 8: Drug Therapy for Parkinsons and Alzheimers Diseases

Question 1

Which of the following neurotransmitters decrease in secretion in Parkinson's disease?

A) norepinephrine
B) serotonin
C) dopamine
D) acetylcholine

Answer 1

dopamine

Question 2

Parkinson's disease usually develops after age:

A) 20
B) 40
C) 60
D) 80

Answer 2

60

Question 3

Anti-Parkinsonism drugs are given to restore the balance of acetylcholine and:

A) serotonin
B) dopamine
C) melatonin
D) melanin

Answer 3

dopamine

Question 4

The FDA has approved only a few medications for Alzheimer's diseases, classified as:

A) antimetabolites
B) anticholinergics
C) anticonvulsants
D) acetylcholinesterase inhibitors

Question 5

Which of the following drugs may cause darkened urine?

A) donepezil (Aricept )
B) tacrine (Cognex )
C) galantamine (Reminyl )
D) rivastigmine (Exelon )

Question 6

A decrease in spontaneity and movement, as seen in Parkinson's disease, is known as:

A) tremor
B) muscular dystrophy
C) bradykinesia
D) bradycardia

Question 7

Which of the following is NOT a degenerative disease of the CNS?

A) Huntington's chorea
B) Parkinson's disease
C) epilepsy
D) Alzheimer's disease

Question 8

Anti-Parkinsonism drugs are administered to restore the balance of dopamine and acetylcholine in which part of the brain?

A) cerebellum
B) corpus stratum
C) mid-brain
D) pons

Question 9

Which of the following is the drug of choice for Parkinson's disease?

A) bromocriptine
B) pramipexole
C) selegiline
D) levodopa

Question 10

Which of the following is a precursor of dopamine formation?

A) bromocriptine
B) levodopa
C) selegiline
D) pramipexole

Question 11

Which of the following terms means "grinding of teeth"?

A) trembling
B) atrophy
C) bruxism
D) bradykinesia

Question 12

How long should patients receive pharmacotherapy for Alzheimer's disease prior to amassing maximum benefits of drug therapy?

A) 2 weeks
B) 6 weeks
C) 2 months
D) 6 months

Question 13

Which of the following substances cannot cross the blood-brain barrier?

A) epinephrine
B) acetylcholine
C) dopamine
D) norepinephrine

Question 14

Amantadine is used in the treatment of Parkinson's disease and also for:

A) bacterial infections
B) viral disorders
C) numbness of fingers
D) hypotension

Question 15

Anticholinergic drugs should be used cautiously in patients with which of the following?

A) hypertension
B) cardiac arrhythmias
C) liver dysfunction
D) all of the above

Question 16

Acetylcholinesterase inhibitors elevate which of the following substances in the brain?

A) serotonin
B) acetylcholine
C) adrenaline
D) none of the above

Question 17

Anticholinergic drugs are contraindicated in patients with:

A) peptic ulcers
B) chorea
C) postural tremor
D) Parkinsonism

Question 18

Which of the following is an indication of acetylcholinesterase inhibitors?

A) seizure disorders
B) enlargement of the prostate
C) dementia of the Alzheimer's type
D) hepatic disease

Question 19

Which of the following is considered the drug of choice for Parkinson's disease?

A) donepezil (Aricept )
B) tacrine (Cognex )
C) amantadine (Symmetrel )
D) levodopa (Larodopa )

Question 20

Patients taking levodopa should be monitored for which of the following symptoms?

A) resting tremors
B) orthostatic hypotension
C) muscular rigidity
D) postural instability

Question 21

Match the generic name to the trade name.

-procyclidine

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 22

__________ is a state of extremely slow movements, as seen in Parkinson's disease.

Question 23

Parkinson's disease causes dysfunction and changes in the __________ __________ in the brain.

Question 24

Drug-induced Parkinson's disease is particularly linked to use of __________ such as chlorpromazine.

Question 25

Anti-parkinsonism drugs are administered to restore the balance of dopamine and __________ in the basal ganglia.

Question 26

__________ is the drug of choice for Parkinson's disease.

Question 27

Dopaminergic agents restore the neurotransmitter __________ in the extrapyramidal region of the brain.

Question 28

__________ drugs inhibit acetylcholine in the central nervous system.

Question 29

Anticholinergic drugs should be used cautiously in patients with cardiac __________, hypertension, hypotension, and liver dysfunction.

Question 30

The exact cause of Alzheimer's disease is __________.

Question 31

Acetylcholinesterase inhibitors are __________ acting agents.

Question 32

Acetylcholinesterase inhibitors are used in the treatment of mild to moderate __________ of Alzheimer's disease.

Question 33

Acetylcholinesterase inhibitors are contraindicated in patients with liver or __________ impairment.

Question 34

The trade name of amantadine is __________.

Question 35

The trade name of pramipexole is __________.

Question 36

Alzheimer's disease is one of the most common causes of severe __________ dysfunction.

Question 37

Levodopa should be avoided in patients with __________-angle glaucoma.

Question 38

The trade name for benztropine is __________.

Question 39

Levodopa can __________ the blood-brain barrier.

Question 40

The term __________ means "wasting away".

Question 41

Match the generic name to the trade name.

-carbidopa-levodopa

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 42

Match the generic name to the trade name.

-pergolide

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 43

Match the generic name to the trade name.

-tolcapone

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 44

Match the generic name to the trade name.

-ropinirole

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 45

Match the generic name to the trade name.

-bromocriptine

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 46

Match the generic name to the trade name.

-trihexyphenidyl

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 47

Match the generic name to the trade name.

-biperiden

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 48

Match the generic name to the trade name.

-benztropine

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane

Question 49

Match the generic name to the trade name.

-diphenhydramine

A)Parlodel
B)Requip
C)Tasmar
D)Sinemet
E)Permax
F)Kemadrin
G)Cogentin
H)Benadryl
I)Akineton
J)Artane