Deck 15: Drugs for Coagulation Disorders

Question 1

Why is hemostasis important? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

A) To protect the body from both external and internal injuries
B) To prevent shock and death due to bleeding from wounds
C) To maintain a delicate balance between blood fluidity and coagulation
D) To maintain body temperature in times of stress

Answer 1

To protect the body from both external and internal injuries
To prevent shock and death due to bleeding from wounds
To maintain a delicate balance between blood fluidity and coagulation

Question 2

What happens in the coagulation cascade when prothrombinase is activated after an injury?

A) Fibrinogen changes to fibrin
B) Prothrombin changes to thrombin
C) Plasminogen changes to plasmin
D) Thrombin changes to prothrombin

Answer 2

Prothrombin changes to thrombin

Question 3

A clot within an artery that blocks blood flow to the brain is called:

A) Myocardial infarction
B) Deep vein thrombosis
C) Cerebrovascular accident (CVA)/stroke
D) Deep vein thrombosis (DVT)

Answer 3

Cerebrovascular accident (CVA)/stroke

Question 4

A patient has been prescribed an antiplatelet drug, and asks the pharmacist to explain why this medication has been prescribed. Which response by the pharmacist is the most appropriate?

A) "These medications are used to dissolve such life-threatening clots."
B) "These medications are used to prevent clot formation in arteries."
C) "These medications are used to prevent the formation of clots."
D) "These medications inhibit the normal removal of fibrin, thus keeping the clot in place for a longer period of time."

Question 5

A patient has been prescribed clopidogrel. The pharmacist instructs the patient that which types of drugs can increase the risk for bleeding? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

A) Anticoagulants
B) Ibuprofen
C) Thrombolytic agents
D) Some antibiotics
E) Aspirin

Question 6

What are the primary subclasses of antiplatelet agents? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

A) Thrombolytics
B) Aspirin (ASA)
C) Adenosine diphosphate (ADP) receptor blockers
D) Glycoprotein IIb/IIIa receptor blockers
E) Antipyretic agents

Question 7

A patient has been prescribed a subcutaneous anticoagulant. Which anticoagulant can the nurse administer subcutaneously? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

A) Lepirudin
B) Dalteparin
C) Enoxaparin
D) Warfarin
E) Insulin

Question 8

Too much clotting can be just as deadly as too little.

Question 9

Thrombin causes the change of plasminogen to plasmin, which causes the formation of fibrin strands and a clot.

Question 10

An embolism is a thrombus or clot which has moved from its origin.

Question 11

Heparin works on thrombin while warfarin works on prothrombin formation, which is why warfarin works immediately.

Question 12

Patients on warfarin should not eat large or inconsistent amounts of foods high in vitamin K (e.g., broccoli) because it interferes with clotting time.

Question 13

The therapeutic effect of thrombolytics is greater when they are administered as soon as possible after clot formation occurs, preferably within 48 hours.

Question 14

What is the rationale for a doctor prescribing a daily dosage of baby aspirin for a client with thromboembolic disease?

Question 15

Taking into account the steps to achieve fibrinolysis, indicate where/how antifibrinolytics and thrombolytics work.

Question 16

Why is heparin started in the hospital after an MI yet the patient goes home on warfarin?