Deck 18: The Chemical Literature

Question 1

Using the Handbook of Chemistry and Physics, find the melting points of the following com- pounds.
(a) trans-1,2-Cyclohexanedicarboxylic acid
(b) m-Aminophenol
(c) 2,5-Dibromofuran

Answer 1

(a) 179-183?
(b) 123?
(c) 9-10?

Question 2

Using Lange's Handbook of Chemistry, find the refractive index of each of the following com- pounds.
(a) Benzyl alcohol
(b) Formamide
(c) 3-Pentenoic acid chloride

Answer 2

(a) 1.5396 (20˚)
(b) 1.4472 (20˚)
(c) 1.448 (20˚)

Question 3

Using the Merck Index, find the following information.
(a) The medical use of a-methyl-p-tyrosine
(b) The structure and primary literature reference to tocol
(c) What the Wenker ring closure is

Answer 3

(a) Inhibitor of catecholamine synthesis, antihypertensive in pheochromocytoma.
(b) Pendse, Karrer, Helv. Chim. Acta. 1957, 40, 1837.
(c) The formation of aziridines by distilling the sulfate salts of alpha-amino alcohols with alkali:

Question 4

Use Chemical Abstracts to find the CAS RN for the following compounds.
(a) 1-Cyclohexyl-2-propyn-1-ol
(b) Marvinol 2002

Question 5

Use Chemical Abstracts to find the name and molecular formula of the compound with the CAS RN [1226-05-7].

Question 6

Use Chemical Abstracts to find all articles that Tarek Sammakia published in 1996.

Question 7

(Note: The next two problems require access to online resources. The answers are available in SciFinder as of July 2000 and not only will vary, but will change as new articles are published. The purpose of these questions is to get students started in online searches; the answers to the questions are
not as important as this stated purpose.)
-Write down the name of an ingredient listed on a bottle at home. The bottle can be a cleaning item, a medication, a food: whatever you wish. Search for the compound in the Merck Index or in SciFinder. Print the information you find about the compound.

Question 8

(Note: The next two problems require access to online resources. The answers are available in SciFinder as of July 2000 and not only will vary, but will change as new articles are published. The purpose of these questions is to get students started in online searches; the answers to the questions are
not as important as this stated purpose.)
-Use the Merck Index and SciFinder to find out about one of the following topics. Go first to the word in italics and look it up in the Merck Index. Print the record and highlight the CAS registry number. Use this number to help you search SciFinder for the desired information. Print the abstract. Circle the document type; if it is a journal, highlight the journal name.
(a) Uses for ferrocene-treated zeolite catalysts
(b) The role of benzoic acid in the protection of trembling aspens
(c) Find information on the effectiveness of an arginine derivative of ibuprofen in pain man- agement