Deck 14: Alterations in Hemostasis and Blood Coagulation

Question 1

Dysfunction of which organ would lead to clotting factor deficiency?

A) Liver
B) Kidney
C) Spleen
D) Pancreas

Answer 1

Liver

Question 2

A deficiency of von Willebrand factor impairs

A) activation of the coagulation cascade.
B) platelet aggregation.
C) platelet adhesion to injured tissue.
D) platelet production.

Answer 2

platelet adhesion to injured tissue.

Question 3

The activated partial thromboplastin time (aPTT)is a measure of the integrity of

A) the extrinsic pathway.
B) the intrinsic pathway.
C) factor VIII synthesis.
D) plasminogen.

Answer 3

the intrinsic pathway.

Question 4

The megakaryocyte is a precursor to

A) factor IX.
B) white blood cells.
C) red blood cells.
D) platelets.

Question 5

The final step in clot formation is

A) conversion of prothrombin to thrombin.
B) platelet degranulation and adhesion.
C) conversion of fibrinogen to fibrin.
D) clot retraction.

Question 6

Disseminated intravascular coagulation may be treated with heparin therapy to

A) enhance fibrinolysis.
B) inhibit clotting factor consumption.
C) activate platelets.
D) enhance liver synthesis of clotting factors.

Question 7

Which involves bleeding associated with vascular or platelet defects?

A) Bleeding that occurs immediately after trauma
B) Bleeding that involves skin or mucous membranes
C) Bleeding that is brief in duration
D) Bleeding that is delayed
E) Bleeding into muscles or joints

Question 8

A normal bleeding time in association with normal platelet count, and increased prothrombin time (PT)and INR, is indicative of

A) vitamin K deficiency.
B) hemophilia B.
C) hemophilia A.
D) idiopathic thrombocytopenia.

Question 9

A newborn has melena, bleeding from the umbilicus, and hematuria.The newborn most likely experiencing

A) vitamin K deficiency bleeding.
B) acquired vitamin K deficiency.
C) von Willebrand disease.
D) disseminated intravascular coagulation.

Question 10

Activation of the extrinsic pathway of coagulation is initiated by

A) platelet factors.
B) collagen exposure.
C) tissue thromboplastin.
D) factor VII.

Question 11

A 3-year-old boy who exhibits prolonged bleeding after minor trauma and a prolonged aPTT, but a normal platelet count, is likely to be diagnosed with

A) hemophilia.
B) liver dysfunction.
C) disseminated intravascular coagulation.
D) thrombocytopenia.

Question 12

A commonly ingested substance associated with prolongation of the bleeding time is

A) acetaminophen.
B) tobacco.
C) caffeine.
D) aspirin.

Question 13

The conversion of plasminogen to plasmin results in

A) clot retraction.
B) fibrinolysis.
C) platelet aggregation.
D) activation of thrombin.

Question 14

What is involved in the release of plasminogen activators?

A) Factor X
B) Factor XII
C) HMWK
D) Kallikrein
E) Thrombin

Question 15

A patient is diagnosed with a tortuous blood vessel of the right hand that bleeds spontaneously.This patient presents with

A) petechiae.
B) purpura.
C) telangiectasia.
D) thrombocytosis.

Question 16

A patient presents to the physician's office with pinpoint hemorrhages on the skin.The patient is most likely between the ages of _____ years.

A) 6 months and 2
B) 4 and 7
C) 15 and 18
D) 25 and 45

Question 17

A cause of thrombocytopenia includes

A) hypoxemia.
B) reduced erythropoietin.
C) chemotherapy.
D) secondary polycythemia.

Question 18

The prothrombin time (PT)and INR (International Normalized Ratio)measure the integrity of

A) platelet function.
B) extrinsic pathway.
C) intrinsic pathway.
D) fibrinolysis.

Question 19

Widespread activation of the clotting cascade secondary to massive trauma is called

A) hemophilia B.
B) disseminated intravascular coagulation (DIC).
C) Hageman disease.
D) idiopathic thrombocytopenia purpura.

Question 20

Treatment for hemophilia A includes

A) heparin administration.
B) factor IX replacement.
C) factor VIII replacement.
D) platelet transfusion.

Question 21

A male patient involved in a motor vehicle accident is brought to the emergency department with acute flank pain.What additional signs of bleeding may the patient exhibit?

A) Hematuria
B) Melena
C) Hematemesis
D) Menorrhagia
E) Hemoptysis

Question 22

Which diseases may be associated with a bleeding problem?

A) Urinary retention
B) Renal failure
C) Cirrhosis
D) Systemic lupus erythematosus
E) Ovarian cancer

Question 23

The ________ is responsible for the synthesis of coagulation factors, with the exception of part of factor VIII.

Question 24

Hemophilia B is also known as ________ disease.