Deck 18: Human Histocompatibility

Question 1

The HLA class II genetic region is divided into which subregions?

A)DOA,DOB,DMA,DMB
B)DP,DO/DM,DQ,DR
C)HLA-A,HLA-B,HLA-C
D)MIC-A,MIC-B

Answer 1

DP,DO/DM,DQ,DR

Question 2

When discussing the 2010 naming convention,all of the following statements are true except

A)The first set of numbers is called the allele family.
B)The second set of numbers is assigned in order of the allele's discovery.
C)The third set of numbers differentiates alleles that have different DNA sequences in the noncoding areas of the gene.
D)The fourth set of numbers refers to differences in the untranslated end pieces of DNA.

Answer 2

The third set of numbers differentiates alleles that have different DNA sequences in the noncoding areas of the gene.

Question 3

Which of the following is the correct term used for "multiple genes expressed in an individual that produce similar products"?

A)Polymorphic
B)Polygenic
C)Polymerase
D)Pseudogene

Answer 3

Polygenic

Question 4

If all possible alleles have the same nucleotide sequence in the exons coding for the peptide-binding domains,the string is reported as the possible allele with the lowest number followed by a capital

A)A
B)D
C)G
D)P

Question 5

In humans the major histocompatibility complex (MHC)is also called the _____ system.

A)DRA
B)HAL
C)HLA
D)MIC

Question 6

Which of the following are molecules produced and secreted by activated cells?

A)Cytokines
B)Cytometries
C)Cytosines
D)Cytosols

Question 7

All of the following are typical monitoring tests performed after a kidney transplant except

A)C4D staining and histological analysis
B)Serum creatinine level
C)Serum complement level
D)Urinary output

Question 8

How many DRB genes exist in the human population?

A)1
B)5
C)9
D)10

Question 9

Which HLA class of molecules is used in solid phase assays?

A)Class I only
B)Class II only
C)Class III only
D)Class I or II

Question 10

When matching a recipient and potential donor for kidney transplant,all of the following antigens should be identified except

A)HLA-A
B)HLA-B
C)HLA-DQ
D)HLA-DR

Question 11

When matching a recipient and donor for hematopoietic progenitor cell (HPC)transplant,how many alleles should be identified in the donor and recipient?

A)8
B)10
C)12
D)16

Question 12

All of the following describe the adaptive immune system except

A)Also known as the natural immune system
B)Consists of antigen presenting cells
C)Displays an anamnestic response
D)Is involved in allograft rejection

Question 13

Which of the following methods is typically used to crossmatch a recipient's serum with donor lymphocytes?

A)Flow cytometry
B)Sequence-specific primer typing
C)Signal transduction
D)Solid phase assay

Question 14

Which chromosome carries the genes for the HLA system?

A)1
B)3
C)6
D)9

Question 15

What is the best description of a CREG?

A)Group of alleles on the same chromosome that are often inherited together
B)Group of antigens that all react with an antibody directed against a common epitope
C)Group of antigens resulting from alleles that are independently segregated
D)Group of HLA antibodies that react with a particular epitope common to multiple bacteria

Question 16

All of the following are true about HLA class I molecules except

A)Are expressed only on antigen presenting cells
B)Includes a 45 kDa α glycoprotein heavy chain
C)Includes a 12 kDa β-2 microglobulin light chain
D)Has a peptide-binding cleft that reacts with short peptides

Question 17

The SSO (sequence-specific oligonucleotide)probe hybridization method

A)begins with amplification of the target DNA
B)determines the nucleotide sequence of the entire exon
C)employs primer pairs that are specific for unique sequences within an exon
D)uses two rounds of polymerase chain reaction (PCR)

Question 18

Which type of transplant is frequently used to treat genetic and acquired dysfunction of the bone marrow?

A)Bone
B)B lymphocyte cell
C)Hematopoeitic progenitor cell
D)Liver

Question 19

Which antigen would not be considered a Class I antigen?

A)HLA-A
B)HLA-B
C)HLA-C
D)HLA-D

Question 20

A crossmatch using autologous lymphocytes can indicate if which of the following is present?

A)Alloantibodies
B)Autoantibodies
C)IgG
D)IgM