Deck 4: Abo and Hh Blood Group Systems

Question 1

In order to avoid the chance of an acute hemolytic transfusion reaction,most laboratories will transfuse only group ____ red blood cell units and group ____ plasma products to patients who have an unresolved ABO-typing discrepancy.

A)A,AB
B)B,AB
C)O,AB
D)A,B

Answer 1

O,AB

Question 2

Alloantibodies that cause problems in ABO typing include

A)anti-Jkᵃ
B)anti-P1
C)A₁ lectin
D)A₂ lectin

Answer 2

anti-P1

Question 3

What is the immunodominant sugar of the A antigen?

A)D-galactose
B)D-glucose
C)N-acetyl-D-galactosamine
D)L-fucose

Answer 3

N-acetyl-D-galactosamine

Question 4

To confirm anti-A₁ in a person who has not been recently transfused,type the patient/donor cells with

A)anti-A₁ lectin
B)anti-A₂ lectin
C)anti-B lectin
D)anti-O lectin

Question 5

ABO discrepancies are categorized into ____ groups.

A)two
B)three
C)four
D)five

Question 6

The gene for the ABO blood group system resides on chromosome

A)3
B)5
C)9
D)11

Question 7

Forward grouping

A)Identifies antibody by combining the unknown plasma with known ABO red blood cells
B)Identifies antigen by combining the unknown red blood cells with known antibody
C)Occurs when the results of the forward and reverse grouping do not correlate
D)Occurs when the results for the A and B antigen do not correlate

Question 8

Mixed field reaction is commonly seen in the forward ABO test if a group _________ patient has received an emergency transfusion of group ____ cells.

A)A,A
B)A,B
C)A,O
D)O,O

Question 9

The red blood cells of the Bombay phenotype appear to be group ____ in routine ABO testing.

A)A
B)B
C)AB
D)O

Question 10

Which gene produces an enzyme that attaches an immunodominant sugar to type 1 precursor substance to form the H antigen?

A)h
B)H
C)se
D)Se

Question 11

Most ABO antibodies are

A)IgA
B)IgE
C)IgG
D)IgM

Question 12

Antibodies that develop without any apparent stimulus are called

A)Actively occurring
B)Innately occurring
C)Naturally occurring
D)Passively occurring

Question 13

Cold-reactive alloantibodies can be identified by testing plasma against panels of cells with known

A)antibodies
B)genes
C)microorganisms
D)phenotypes

Question 14

The most common ABO blood group is group

A)A
B)B
C)AB
D)O

Question 15

How many nucleotide differences are there between the A and B genes?

A)3
B)4
C)6
D)7

Question 16

Which of the following individuals first described the ABO blood group system?

A)Decastello
B)Landsteiner
C)Sturli
D)Yamamoto

Question 17

Which gene is an amorph,meaning no functional gene product is produced from this sequence of DNA?

A)A
B)B
C)H
D)O

Question 18

If an ABO discrepancy is due to an antibody and a low-incidence antigen is suspected,a viable course of action would be to test several different examples of

A)A or B cells
B)A or O cells
C)B or O cells
D)AB cells

Question 19

Possible causes of a missing or weak reaction in the forward group include all of the following except

A)Disease that alters the ABO antigen expression
B)Excessive soLuᵇle ABO antigens in patient/donor's plasma
C)Hypogammaglobulinemia
D)Transfusion or transplantation

Question 20

All of the following are true of the cis-AB genotype except

A)May be easily distinguished in routine laboratory testing
B)May occur in a child if a crossover event happened to one of the parent's chromosomes
C)May result from a mutation that produces an unusual enzyme
D)May result from both the A and B genes residing on one chromosome