Deck 11: Treatment of Migraine Headache and Alzheimers Disease

Question 1

When using a triptan to treat a migraine,which route of administration produces the best results?

A)subcutaneous injection
B)intranasal administration
C)oral formulation
D)any of the above

Answer 1

A
The triptans are available for administration by mouth,subcutaneous injection,and intranasal use.Subcutaneous injection produces the most rapid response and is the most effective route of administration;however,intranasal administration is also rapid and has fewer adverse reactions.Oral formulations have a slower onset of action.

Question 2

Which of the following does not trigger a migraine?

A)release of vasoactive neuropeptides
B)clumping platelets causing release of serotonin
C)release of neurotransmitter norepinephrine
D)release of prostaglandins

Answer 2

C
The trigger sets off a series of events that starts with the release of vasoactive neuropeptides that cause blood vessels in the brain to first constrict and then dilate.The trigger produces vasospasms and that reduce blood flow to the brain.Platelets in the blood clump together and cause the release of serotonin,which further constricts blood vessels.This trigger sets off afferent signals via the trigeminal nerve to release prostaglandins and other neurochemicals that dilate blood vessels,produce inflammation,and stimulate nociceptors.

Question 3

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
rivastigmine

Answer 3

H

Question 4

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
donepezil

Question 5

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
zolmitriptan

Question 6

Which of the following statements about triptans is not true?

A)Triptans are the most widely prescribed drugs for the treatment of acute migraine headaches.
B)The triptans are selective serotonin (5-HT)receptor agonists and stimulate vasoconstriction.
C)Triptans that have a long half-life,frovatriptan (T 1/2 24 hours)and naratriptan (T 1/2 8 hours),are more effective in preventing headache reoccurrence.
D)The use of triptans is restricted to a maximum of 4 to 6 doses per 24 hours.

Question 7

Of the five drugs currently approved for the treatment of Alzheimer's disease,which one of them is not an acetylcholinesterase inhibitor?

A)tacrine (Cognex)
B)donepezil (Aricept)
C)memantine (Namenda)
D)rivastigmine (Exelon)

Question 8

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
sumatriptan

Question 9

All of the following are used for treatment of migraines except _____.

A)serotonin antagonists
B)ergot alkaloids
C)antiseizure medications
D)MAOI antidepressants

Question 10

Alzheimer's disease causes damage to the _____,the part of the brain that is involved in memory.

A)cerebellum
B)hippocampus
C)medulla
D)thalamus

Question 11

_____ is a neurodegenerative disease that causes memory loss,behavioral changes,and immobility.

A)Parkinson's disease
B)Multiple sclerosis
C)Cerebrovascular accident
D)Alzheimer's disease

Question 12

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
tacrine

Question 13

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
ergotamine tartrate

Question 14

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
naratriptan

Question 15

The most significant neurotransmitter that plays a significant role in Alzheimer's disease is _____.

A)dopamine
B)norepinephrine
C)acetylcholine
D)serotonin

Question 16

MATCHING
Matching the following trade and generic drug names:
a.Aricept
b.Zomig
c.Cognex
d.Imitrex
e.Cafergot
f.Amerge
g.Namenda
h.Exelon
memantine