Deck 26: Treatment of Gastroesophageal Reflux Disease,laryngopharyngeal Reflux and Peptic Ulcer Disease

Question 1

The treatment of GERD,LPR,and PUD is aimed at _____.

A)reducing gastrointestinal irritants
B)increasing protective factors
C)eliminating stomach acid
D)a and b

Answer 1

D
The treatment of GERD,LPR,and PUD is aimed at reducing gastrointestinal irritants (i.e. ,the volume of gastric acid,digestive enzymes such as pepsin)and increasing protective factors (i.e. ,mucus secretion by epithelial cells).

Question 2

Which of the following is not characteristic of an ulcer?

A)open sore
B)open wound
C)can occur anywhere in the body
D)limited to the digestive system

Answer 2

D
An ulcer is an open wound or sore.Ulcers can occur anywhere on the body.

Question 3

Persons of any age,even infants,can develop GERD.

Answer 3

True
Persons of any age can develop GERD.Infants may have GERD because their digestive system is immature.

Question 4

All of the following medications can cause an ulcer to develop except _____.

A)aspirin
B)NSAIDs
C)misoprostol
D)corticosteroids

Question 5

Antacids are the oldest drugs used in the treatment of GERD and PUD.

Question 6

Which of the following pairs of drugs are proton pump inhibitors?

A)omeprazole and ketoconazole
B)esomeprazole and lansoprazole
C)pantoprazole and miconazole
D)omeprazole and nizatidine

Question 7

An example of a mucosal protectant that decreases the susceptibility of epithelial cells that line the stomach and small intestine to damage by gastric acids,pepsin,and H.pylori is _____.

A)Protonix
B)misoprostol
C)metoclopramide
D)Aciphex

Question 8

Proton pump inhibitors (PPIs)work by _____.

A)decreasing gastric acids by interfering with the final step in gastric acid production
B)interfering with hydrogen and potassium ion exchange
C)a and b
D)none of the above

Question 9

Gastroesophageal reflux disease (GERD)is a motility disorder associated with impaired digestion.

Question 10

Which of the following does not aggravate GERD?

A)smoking
B)alcohol
C)exercise
D)diet

Question 11

Prokinetic drugs used for the treatment of GERD and LPR work by _____.

A)increasing peristalsis
B)speeding up gastric emptying
C)improving lower esophageal sphincter tone
D)all of the above

Question 12

Cimetidine is 10 times more potent ad more effective than ranitidine.

Question 13

Which sphincter in the digestive system is affected by GERD?

A)duodenal sphincter
B)pyloric sphincter
C)lower esophageal sphincter
D)laryngeal sphincter

Question 14

Which of the following H₂ receptor antagonists can cause the development of gynecomastia in men and inhibit several cytochrome P450 metabolic enzymes and is responsible for increasing the elimination of more than 25 different drugs?

A)cimetidine
B)famotidine
C)nizatidine
D)ranitidine

Question 15

Which of the following class of drugs is used to treat GERD,LPR,and PUD?

A)H₁ receptor antagonists
B)H₂ receptor antagonists
C)antihistamines
D)bile acid sequestrants

Question 16

There are some prescription and OTC medicines that can worsen GERD.

Question 17

Proton pump inhibitors are effective in treating GERD,LPR,and PUD because they _____.

A)decrease gastric acid
B)block histamine
C)decrease respiratory mucus
D)none of the above

Question 18

The only proton pump inhibitor available OTC is _____.

A)lansoprazole
B)pantoprazole
C)omeprazole
D)rabeprazole

Question 19

Which of the following pairs of drugs are H₂ receptor antagonists?

A)Prilosec and cimetidine
B)Prevacid and ranitidine
C)famotidine and diphenhydramine
D)ranitidine and famotidine

Question 20

Nearly two-thirds of the global population is infected with ______ bacteria,and it is the number one cause of peptic ulcer disease.

A)Streptococcus
B)Helicobacter pylori
C)Staphylococcus
D)Helicobacter spirilla

Question 21

_____ is currently the only prokinetic drug approved by the FDA.

A)Pantoprazole
B)Misoprostol
C)Metoclopramide
D)Sucralfate

Question 22

For which of the following gastrointestinal disease states are antimicrobials prescribed?

A)GERD
B)LPR
C)PUD
D)PID

Question 23

Which of the following pairs of antacids cause diarrhea and constipation?

A)calcium and aluminum
B)magnesium and sodium
C)calcium and magnesium
D)sodium and calcium