Deck 38: Vaccines,immunomodulators,and Immunosuppressants

Question 1

The immunomodulator basiliximab is used to _____.

A)prolong the life of transplanted organs
B)reduce transplant rejections
C)encourage T-cell proliferation
D)a and b

Answer 1

D
Basiliximab,daclizumab,and muromonab are monoclonal antibody immunomodulators that are used to reduce transplant rejections and to prolong the life of transplanted organs.

Question 2

Immunosuppressants are used for all of the following disease states except _____.

A)multiple sclerosis
B)muscular dystrophy
C)rheumatoid arthritis
D)systemic lupus erythematosus

Answer 2

B
Drugs that have their primary action on cells of the immune system are used in the treatment of autoimmune diseases such as multiple sclerosis,rheumatoid arthritis,systemic lupus erythematosus (Chapter 15),and Crohn's disease.

Question 3

A common ending for monoclonal antibody immunomodulators is _____.

A)"-tan"
B)"-mab"
C)"-ine"
D)"-olol"

Answer 3

B
TECH NOTE: A common ending for monoclonal antibody immunomodulators is "-mab."

Question 4

An example of a conjugate vaccine is _____.

A)Haemophilus influenzae type B (Hib)
B)flu
C)mumps
D)all of the above

Question 5

Which of the following classification of drugs are not categorized as immunopharmacologicals?

A)corticosteroids
B)antineoplastics
C)antivirals
D)cytokine inhibitors

Question 6

Which of the following is not an example of a live vaccine?

A)polio
B)mumps
C)tetanus
D)rubella

Question 7

Mycophenolic acid is an immunosuppressive agent that inhibits the enzyme required for synthesis of purines needed for _____.

A)T-cell proliferation
B)B-cell proliferation
C)B-cell antibodies
D)a and b

Question 8

Sirolimus interferes with a key enzyme that regulates the second phase of T-cell activation and proliferation and decreases levels of all of the following immunoglobulins except _____.

A)IgM
B)IgG
C)IgD
D)IgA

Question 9

Vaccines that stimulate the immune system to produce antibodies to the toxins that cause illness (e.g. ,tetanus and diphtheria)are _____ vaccines.

A)conjugated
B)live,attenuated
C)toxoid
D)inactivated,killed

Question 10

Which of the following entities must keep the cold chain for vaccines and immunologicals unbroken?

A)manufacturer
B)pharmacy
C)physician's office or clinic
D)all of the above

Question 11

Antithymocyte globulin ATG is primarily administered to _____.

A)reduce rejection associated with organ and bone marrow transplantation.
B)boost the immune system of the immunosuppressed patient
C)provide protection against infections attacking the immunosuppressed patient
D)none of the above

Question 12

All of the following vaccines are inactivated,killed vaccines except _____.

A)flu
B)hepatitis A
C)polio
D)diphtheria

Question 13

A living,but weakened,version of the invader that does not cause disease (nonvirulent)is called _____ vaccine.

A)live,attenuated
B)dead,attenuated
C)live,encapsulated
D)live,strengthened

Question 14

Immunopharmacologicals that inhibit cell proliferations are known as _____.

A)immunostimulants
B)immunosuppressants
C)immunologicals
D)immunostabilizers

Question 15

The temperature that must be maintained for an uninterrupted cold chain from the manufacturer to its final destination is _____.

A)2° C to 6° C
B)2° C to 8° C
C)32° F to 59° F
D)59° F to 86° F

Question 16

MATCHING
Match the following trade and generic drug names.
a.CellCept
b.Enbrel
c.Kinaret
d.Xenapax
e.Sandimmune
anakinra

Question 17

Rh0 [D] immune globulin is administered to pregnant women who are _____ and who have been _____.

A)Rh (-),exposed to blood that is Rh (+)
B)Rh (+),exposed to blood that is Rh (-)
C)Rh (0),exposed to blood that is Rh (-)
D)a and b

Question 18

Which of the following drugs is used to improve survival rates for individuals with organ transplants and works by suppressing cell destruction in graft-versus-host reactions?

A)tacrolimus
B)cyclosporine
C)Atgam
D)CellCept

Question 19

An example of a genetically engineered inhibitor of tissue necrosis factor (TNF)-α that blocks the inflammatory process triggered by high concentrations of TNF is _____.

A)anakinra
B)RhoGAM
C)etanercept
D)muromonab

Question 20

The flu vaccine must be reformulated every _____.

A)6 months
B)year
C)24 months
D)5 years

Question 21

MATCHING
Match the following trade and generic drug names.
a.CellCept
b.Enbrel
c.Kinaret
d.Xenapax
e.Sandimmune
etanercept

Question 22

MATCHING
Match the following trade and generic drug names.
a.CellCept
b.Enbrel
c.Kinaret
d.Xenapax
e.Sandimmune
mycophenolate mofetil

Question 23

MATCHING
Match the following trade and generic drug names.
a.CellCept
b.Enbrel
c.Kinaret
d.Xenapax
e.Sandimmune
cyclosporine

Question 24

MATCHING
Match the following trade and generic drug names.
a.CellCept
b.Enbrel
c.Kinaret
d.Xenapax
e.Sandimmune
daclizumab