Deck 12: Pharmacogenetics

Question 1

Which of the following should be avoided in an individual with a mutation in the ryanodine receptor RYR1?

A) Anesthesia using halothane
B) Periods of fasting
C) Isoniazid treatment
D) Chemotherapy with 5-fluorouracil
E) Alcohol consumption

Answer 1

Anesthesia using halothane

Question 2

When treated with isoniazid,people who are homozygous for an allele associated with low N-acetyltransferase activity are at risk for which of the following?

A) Inability to maintain sufficient levels of isoniazid for treatment
B) Polyneuritis
C) Inability to absorb sufficient isoniazid
D) Hemolysis
E) Sudden death

Answer 2

Polyneuritis

Question 3

What would you predict about the genes involved in a drug's metabolism if you see a discontinuous dose-response curve in a population?

A) One gene is mainly responsible for the metabolism
B) The number of genes involved in the metabolism is equal to the number of peaks in the response curve
C) There are multiple genes involved in the metabolism, but this would not tell you how many
D) There is a threshold for induction of the gene involved in the metabolism
E) A dose-response curve provides no information on the genetics of drug metabolism

Answer 3

One gene is mainly responsible for the metabolism

Question 4

For the most effective use of Herceptin in breast cancer treatment,molecular testing for which of the following proteins should be performed before the drug is prescribed?

A) BRCA1
B) BRCA2
C) HER2
D) EGFR
E) MTHFR