Question 1

Prostaglandins act via which type of receptor?&#10;A) Ligand-gated ion channel&#10;B) G-protein-coupled receptor&#10;C) Receptor tyrosine kinase&#10;D) Nuclear hormone receptor&#10;E) Cytokine receptor

Accepted Answer

Prostaglandins have heterogeneous effects and as a whole act on the entire range of G-protein-coupled receptors, including Gs, Gi, and Gq. Each prostaglandin has a specific receptor affinity that determines its particular effects.

Question 2

Which of the following enzymes is NOT directly involved in the production of eicosanoids (prostaglandins, leukotrienes, and thromboxane) from the cell membrane lipid bilayer?&#10;A) Lipoxygenase&#10;B) Monoamine oxidase&#10;C) Cyclooxygenase&#10;D) Phospholipase A2&#10;E) Cytochrome P450

Accepted Answer

Monoamine oxidase is not directly involved in eicosanoid production. The other enzymes listed are involved in either the release of arachadonic acid from the cell membrane, or reactions that transform the arachadonic acid into the active substrate.

Deck 15: Prostaglandins and Other Eicosanoids