Question 1

The physiologic difference between temazepam and zolpidem is:&#10;A) Temazepam is a sedative, whereas zolpidem is a hypnotic&#10;B) Temazepam binds to all the GABA-receptor subunits, whereas zolpidem attaches to specific ones only&#10;C) Zolpidem is a benzodiazepine&#10;D) Zolpidem is a also a melatonin agonist&#10;E) Temazepam is a barbiturate

Accepted Answer

The GABA receptor complex has many subunits. Benzodiazapines such as temazepam bind to all subunits irrespective of their composition. Zolpidem is an agonist attaching to only specific receptor subunits, thus its difference in action and adverse effects.

Question 2

The benzodiazepine class of medications:&#10;A) Can be used to effectively control muscle spasms&#10;B) Is not habit forming&#10;C) Has no risk of respiratory depression&#10;D) Acts primarily on the NMDA receptor&#10;E) Does not undergo extensive hepatic metabolism

Accepted Answer

Benzodiazapines have a direct depressant effect on monosynaptic muscle reflex pathways, thus relaxing muscles.

Question 3

The receptors of the GABA complex are variously stimulated by multiple classes of medications including benzodiazapines. The result of such stimulation is:&#10;A) A down regulation of the GABA receptor complex&#10;B) Hyperpolarization of the postsynaptic cell&#10;C) Decreased chloride influx&#10;D) Increased activity of the postsynaptic neuron&#10;E) Decreased seizure threshold

Accepted Answer

Hyperpolarization of the postsynaptic neuron via increased chloride influx leads to a decreased ability for triggering an action potential. This decrease results in inhibition of neural function (sedation).

Deck 31: Treatment of Anxiety and Insomnia