Question 1

Which of the following can be used to stimulate appetite in patients with cachexia?&#10;A) Dronabinol&#10;B) Corticosteroids&#10;C) Progestational agents&#10;D) A and B&#10;E) A, B, and C

Accepted Answer

Dronabinol activates cannabinoid type 1 (CB₁) receptors and therefore appetite. Progestational agents such as megestrol acetate have also been shown to induce weight gain in patients.

Question 2

Sibutramine has which of the following actions?&#10;A) Decreases appetite&#10;B) Decreases thermogenic physiologic pathways&#10;C) Decreases high-density lipoprotein levels&#10;D) Decreases heart rate&#10;E) Decreases blood pressure

Accepted Answer

Sibutramine (Meridia) has two active metabolites that improve lipid profiles in addition to increasing thermogenesis and reducing appetite.

Question 3

The sympathomimetic anti-obesity agents:&#10;A) Are chemically related to norepinephrine and dopamine&#10;B) Include phentermine and orlistat&#10;C) Inhibit GI lipase&#10;D) Have their effect primarily through speeding up metabolism&#10;E) Are Schedule II medications

Accepted Answer

Phentermine is a sympathomimetic indicated for the short-term use of obesity. It suppresses appetite by acting on the hypothalamus. Orlistat decreases intestinal fat absorption.

Deck 33: Treatment of Obesity and Eating Disorders