Deck 9: Musculoskeletal Drugs

Question 1

Which of the following drugs is injected into a joint?

A) betamethasone (Celestone)
B) triamcinolone (Aristospan Intra-articular)
C) hyaluronic acid (Hyalgan, Synvisc)
D) all of the above

Answer 1

all of the above

Question 2

The long-term use of hormone replacement therapy to treat menopause and the symptoms of osteoporosis carries with it the risk of ________.

A) myocardial infarction
B) stroke
C) breast and endometrial cancer
D) all of the above

Answer 2

all of the above

Question 3

Which of the following statements about hyaluronic acid (Hyalgan,Synvisc)is TRUE?

A) Hyaluronic acid is secreted osteoblasts in the bone.
B) It is derived from chili pepper plants.
C) It is also used as a gel-type filler that is injected under the skin to minimize wrinkles.
D) This drug is taken orally to treat osteoarthritis.

Answer 3

It is also used as a gel-type filler that is injected under the skin to minimize wrinkles.

Question 4

William Ruckles has severe rheumatoid arthritis.His physician prescribed ________,an oral gold compound drug.

A) auranofin (Ridaura)
B) raloxifene (Evista)
C) naproxen (Aleve, Naprosyn)
D) capsaicin (Capsin, Zostrix)

Question 5

Which of these drugs has the most powerful anti-inflammatory effect?

A) ibuprofen (Advil, Motrin)
B) acetaminophen (Tylenol)
C) hydrocortisone (Cortef, Solu-Cortef)
D) zoledronic acid (Reclast, Zometa)

Question 6

The hormone cortisol,from which corticosteroid drugs are produced,is secreted by ________.

A) the cortex of the adrenal gland
B) osteoclasts in the bone
C) prostaglandins when there is inflammation
D) inflammation in the joints

Question 7

Drugs used to treat osteoarthritis reduce pain and inflammation by inhibiting the production of ________.

A) antibodies
B) osteoblasts
C) prostaglandins
D) progesterone

Question 8

The normal balance (homeostasis)between new bone deposition and bone resorption (breakdown)is maintained by all of the following,EXCEPT ________.

A) exercise and exposure to the sun
B) parathyroid hormone and calcitonin hormone
C) calcium and vitamin D in the diet
D) all of the above

Question 9

Ibuprofen belongs to what category of drugs?

A) salicylate
B) aspirin
C) skeletal muscle relaxant drug
D) NSAID

Question 10

Rheumatoid arthritis is ________.

A) an autoimmune response of the body's own immune system
B) an allergic reaction
C) a bacterial infection
D) an adverse effect from a drug

Question 11

All of the following are topical drugs used to treat the pain of osteoarthritis,EXCEPT ________.

A) Aspercreme
B) capsaicin (Capsin, Icy Hot)
C) Ascriptin
D) Bengay

Question 12

Risk factors for osteoporosis include all of the following,EXCEPT ________.

A) lack of exercise
B) Caucasian or Asian race
C) weightbearing and constant movement of joints
D) smoking and alcohol use

Question 13

Because of the side effects associated with their prolonged oral use,________ are only prescribed to treat the acute symptoms of osteoarthritis for a limited time.

A) gold compound drugs
B) NSAIDs
C) corticosteroid drugs
D) muscle relaxant drugs

Question 14

All of the following are skeletal muscle relaxant drugs,EXCEPT ________.

A) metaxalone (Skelaxin)
B) alendronate (Fosamax)
C) methocarbamol (Robaxin)
D) cyclobenzaprine (Flexeril)

Question 15

Rheumatoid arthritis is treated with ________.

A) acetaminophen
B) gold compound drugs
C) calcium supplements
D) muscle relaxant drugs

Question 16

Miacalcin,Fosamax,Actonel,and Zometa are all used to treat ________.

A) muscle spasm
B) osteoarthritis
C) osteoporosis
D) pain and inflammation

Question 17

Which of the following statements is TRUE concerning acetaminophen?

A) It inhibits the action of prostaglandins.
B) It is used to treat osteoarthritis.
C) It is an NSAID.
D) All of the above statements are true.

Question 18

Osteoporosis is treated with all of the following types of drugs,EXCEPT ________.

A) selective estrogen receptor modulator drugs
B) NSAIDS
C) bone resorption inhibitor drugs
D) calcium supplements

Question 19

The ending -profen is common to generic ________.

A) gold compound drugs
B) nonsteroidal anti-inflammatory drugs
C) monoclonal antibody drugs
D) drugs used to treat fibromyalgia

Question 20

NSAIDs (nonsteroidal anti-inflammatory drugs)________.

A) are less likely than aspirin to cause gastric irritation or ulcers
B) have a different effect than the drugs naproxen (Aleve) and oxaprozin (Daypro)
C) are more likely than aspirin to cause gastric irritation or ulcers
D) are used to treat both humans and animals in the drug carprofen (Rimadyl).

Question 21

The cause of fibromyalgia is ________.

A) overproduction of prostaglandins
B) muscle spasms in the neck, back, and hips
C) wear and tear in the joints
D) unknown

Question 22

Drugs used to treat osteoarthritis include those that reduce pain and inflammation.Which of the following categories of drugs do not reduce the pain and inflammation of osteoarthritis?

A) COX-2 inhibitor drugs
B) gold compound drugs
C) NSAIDs
D) salicylate drugs

Question 23

________ drugs come in a special arrangement of oral tablets whose number continually decreases each day until the treatment is finished after one week.

A) Bone resorption inhibitor
B) Hyaluronic acid
C) Calcium supplement
D) corticosteroid

Question 24

All of these drugs are combination drugs used to treat osteoporosis.Which one is available as a transdermal patch?

A) Prempro
B) ClimaraPro
C) Activella
D) Femhrt

Question 25

Mature bone is a hard,unchanging substance.

Question 26

Bridget Maurer is taking a monoclonal antibody drug for her rheumatoid arthritis.That drug might include any of the following drugs,EXCEPT ________.

A) abatacept (Orencia)
B) adalimumab (Humira)
C) infliximab (Remicade)
D) golimumab (Simponi)

Question 27

All of the following drugs are used to treat osteoarthritis,EXCEPT ________.

A) muscle relaxant drugs
B) salicylate drugs
C) NSAID and COX-2 inhibitor drugs
D) corticosteroid drugs

Question 28

The therapeutic effect of etanercept (Enbrel)in treating rheumatoid arthritis is that it suppresses the immune response and blocks ________.

A) tumor necrosis factor
B) bone resorption
C) the hormone calcitonin
D) all of the above

Question 29

Only ________ drugs can reverse the cartilage and bone damage that has already occurred in the joints of patients with osteoarthritis.

A) corticosteroid drugs
B) COX-2 inhibitor drugs and NSAIDs
C) monoclonal antibody drugs
D) There are no drugs that can reverse the cartilage and bone damage of osteoarthritis once it has occurred.

Question 30

Which joints are the first to exhibit signs of osteoarthritis with pain,inflammation,and swelling.

A) hips and knees
B) Lower back
C) Fingers and toes
D) all of the above

Question 31

Some hormone replacement drugs used to treat menopause are also indicated for the prevention of osteoporosis.

Question 32

________ is also known as degenerative joint disease.

A) Fibromyalgia
B) Rheumatoid arthritis
C) Osteoarthritis
D) Osteoporosis

Question 33

All of the following are the trade names of nonsteroidal anti-inflammatory drugs,EXCEPT ________.

A) Daypro and Advil
B) Aleve and Clinoril
C) Voltaren and Motrin
D) Skelexin and Flexeril

Question 34

Which of these drugs is NOT used for synovial fluid replacement?

A) Flexeril
B) Hyalgan
C) Synvisc
D) hyaluronic acid

Question 35

Which of the following drugs is used to treat fibromyalgia?

A) The anticonvulsant drug pregabalin (Lyrica)
B) The antidepressant drug duloxetine (Cymbalta)
C) The local anesthetic drug lidocaine (Xylocaine) injected into trigger points
D) all of the above

Question 36

Muscle relaxant drugs specifically relieve muscle ________.

A) inflammation and loss of function
B) pain and inflammation
C) spasms and stiffness
D) malignant hyperthermia

Question 37

The combining form oste/o- (as in osteoarthritis and osteoporosis)means ________.

A) disease
B) bone
C) pain
D) Muscle

Question 38

Gold compound drugs ________.

A) inhibit macrophages from the immune system
B) contain real gold
C) have names that often contain the letters RA, the chemical symbol for gold.
D) A and B

Question 39

Which bone resorption inhibitor drug must be given intravenously?

A) ibandronate (Boniva)
B) alendronate (Fosamax)
C) zoledronic acid (Reclast, Zometa)
D) raloxifene (Evista)

Question 40

Because acetaminophen has no anti-inflammatory action,it is no longer used treat the pain associated with osteoarthritis.

Question 41

The NSAID diclofenac (Voltaren)was the first prescription topical skin gel approved by the FDA for treating the pain of osteoarthritis.

Question 42

Chondroitin,a substance found in the dietary supplement Osteo Bi-Flex,helps cartilage retain its water content.

Question 43

Muscle relaxant drugs are useful in treating the pain and inflammation of osteoarthritis of muscle strains,sprains,and "pulled muscles."

Question 44

Oral gold compound drugs can reverse joint damage that has already occurred in patients with rheumatoid arthritis.

Question 45

In women,parathyroid hormone,calcitonin hormone,calcium in the diet,vitamin D,exercise,and the hormones estradiol and progesterone help prevent rheumatoid arthritis.

Question 46

The drug ibandronate (Boniva)has a unique bone-shaped indentation on its tablet.

Question 47

The topical drug capsaicin is a natural substance derived from chili pepper plants; it makes the skin and joint less sensitive to pain by decreasing nerve signals from sensory nerves.

Question 48

Calcitonin-salmon is the drug form of the body hormone calcitonin.This drug is derived from salmon fish.

Question 49

Drugs that are derivatives of hyaluronic acid are injected into the joints of patients with osteoarthritis to improve the lubricating qualities of the synovial fluid.

Question 50

Indomethacin (Indocin),a drug used to treat osteoarthritis,is also given intravenously to newborn infants to close a persistent patent ductus arteriosus heart defect,an abnormality in the fetal circulation.

Question 51

Some corticosteroid drugs are given as intra-articular injections into a joint affected by osteoarthritis.

Question 52

Naproxen (Aleve,Naprosyn)belongs to the drug category of nonsteroidal anti-inflammatory drugs that are used to treat osteoarthritis.

Question 53

Two COX-2 inhibitor drugs were taken off the market because of an increased risk of heart attacks and strokes.Only one COX-2 inhibitor is currently on the market.

Question 54

The immunomodulator drug leflunomide (Arava),which is used to treat rheumatoid arthritis,is not given to patients with decreased liver function because it has a very long half-life.

Question 55

NSAIDs are structurally similar enough to aspirin that some patients who are allergic to aspirin should not take NSAIDs.

Question 56

Two types of bone cells are constantly at work: Osteoclasts deposit new bone and osteoblasts break down and remove areas of old or damaged bone.

Question 57

The drug diazepam (Valium)is used for muscle relaxation,but it is really an antianxiety drug,not a skeletal muscle relaxant drug.

Question 58

The category of salicylate drugs used to treat osteoarthritis includes aspirin,one of the oldest drugs known to man.

Question 59

The joints have a large number of pain receptors,and damage to the joints can cause chronic,severe pain.

Question 60

Nonsteroidal anti-inflammatory drugs inhibit both the COX-1 and COX-2 enzymes.

Question 61

The ending -mab is common to generic ________ drugs.

Question 62

The endings -lone and -sone are common to generic ________ drugs.

Question 63

The bone resorption inhibitor drug ibandronate (Boniva)is advertised as the osteoporosis drug that is easiest to remember to take because it is taken just once a month.

Question 64

The Janus kinase inhibitor drug tofacitinib is related to the well-known trade name drug ________.

Question 65

________,also known as acetylsalicylic acid (ASA),is the most well-known drug in the salicylate category.

Question 66

Osteoporosis is thinning of the ________ at the cellular level.

Question 67

The endings -dronate and -dronic are common to generic bone resorption inhibitor drugs that are used to treat osteoporosis.

Question 68

In the combination drug Femhrt,used to treat osteoporosis,the hrt stands for ________.

Question 69

Acetaminophen is not used to treat osteoarthritis because it cannot treat ________.

Question 70

The American College of Rheumatology recommends the drug ________ as the drug of choice for treating mild-to-moderate pain associated with osteoarthritis when there is no inflammation involved.

Question 71

Janus kinase (JAK)inhibitor drugs are used to treat fibromyalgia.

Question 72

Physicians and laypersons often refer to intra-articular injections of corticosteroid drugs as "________ shots," but they are not because that drug can only be given orally.

Question 73

COX-2 inhibitor drugs selectively inhibit the COX-2 enzyme,an enzyme that plays a role in the production of ________ that cause the pain and inflammation of osteoarthritis.

Question 74

When you hear the phrase "trigger point injections," you think of a drug being used to treat the disease of ________.

Question 75

Bone resorption inhibitor drugs are also known as bisphosphonate drugs because of their effect on ________ (a component of bone).

Question 76

The abbreviation NSAID stands for ________.

Question 77

The only COX-2 inhibitor drug that is currently on the market is celecoxib,and its trade name is ________.

Question 78

A drug category used to treat osteoporosis is called SERM.The abbreviation SERM stands for ________ drugs.

Question 79

The phrase "low-impact fractures" is associated with the disease of ________.

Question 80

The antacid Tums,which uses calcium to neutralize stomach acid,has advertised that it has a secondary effect of calcium supplementation for women to prevent ________.