Deck 13: Antipsychotic and Antianxiety Drugs

Question 1

Adverse effects of phenothiazine antipsychotics are due to:

A) Stimulation of cholinergic and histamine receptors
B) Blocking of cholinergic and histamine receptors
C) Stimulation of D2 and histamine receptors
D) Blocking of D2 and histamine receptors

Answer 1

Blocking of cholinergic and histamine receptors

Question 2

One way to suppress the symptoms of tardive dyskinesia is by:

A) Supportive therapy
B) Completely discontinuing the antipsychotic drug
C) Tapering the dose of the antipsychotic drug
D) Increasing the dose of the antipsychotic drug

Answer 2

Increasing the dose of the antipsychotic drug

Question 3

All of the following atypical antipsychotic drugs will not produce anticholinergic,alpha-adrenergic blocking,or antihistaminic actions associated with side effects except:

A) Aripiprazole
B) Risperidone
C) Clozapine
D) Olanzapine

Answer 3

Clozapine

Question 4

All of the following represent ways to alleviate parkinsonism which may develop from continued use of a phenothiazine except:

A) Dose reduction
B) Cessation of medication
C) Administer a dopamine agonist
D) Administer a centrally acting anticholinergic

Question 5

A special formulation of which type of atypical antipsychotic would be available for a difficult patient needing immediate treatment from a psychotic episode?

A) Aripiprazole
B) Clozapine
C) Risperidone
D) Olanzapine

Question 6

A beneficial side effect of phenothiazine antipsychotics would be for the treatment of what condition?

A) Hyperthermia
B) Constipation
C) Diarrhea
D) Nausea and vomiting

Question 7

A patient on which type of atypical antipsychotic would be more likely to develop an infection?

A) Aripiprazole
B) Risperidone
C) Clozapine
D) Olanzapine

Question 8

Benzodiazepines rely on ligand-gated _____ channels to achieve their effect of membrane _____.

A) Sodium, depolarization
B) Sodium, hyperpolarization
C) Chloride, depolarization
D) Chloride, hyperpolarization

Question 9

Which of the following antipsychotic medications is more potent,yet displays more of the extrapyramidal syndrome?

A) Thiothixene
B) Chlorpromazine
C) Haloperidol
D) Risperidone

Question 10

Which antipsychotic medication's primary mechanism of action involves reducing activity at serotonin 5HT_2A receptors?

A) Thioridazine
B) Olanzapine
C) Thiothixene
D) Haloperidol

Question 11

An important inhibitory neurotransmitter that keeps emotion and behavior under control is:

A) Dopamine
B) GABA
C) Norepineprine
D) Serotonin

Question 12

Long term use of phenothiazine antipsychotics can result in this serious condition.

A) Parkinsonism
B) Akathesia
C) On-off phenomenon
D) Tardive dyskinesia

Question 13

Atypical antipsychotics differ from the other classes of antipsychotics because they:

A) Have a greater impact on reducing dopamine activity over serotonin activity
B) Have a greater impact on reducing dopamine activity over acetylcholine activity
C) Have a greater impact on reducing serotonin activity over dopamine activity
D) Have a greater impact on reducing acetylcholine activity over dopamine activity

Question 14

Situations that bring about stress and anxiety in a person will directly result in increased activity of which part of the brain?

A) Limbic system
B) Substantia nigra
C) Hippocampus
D) Thalamus

Question 15

Long-acting benzodiazepines are inactivated by _____.

A) Hyaluronic acid which forms an inactive metabolite
B) Glucuronic acid which forms an inactive metabolite
C) Ascorbic acid which forms an inactive metabolite
D) Linoleic acid which forms an inactive metabolite

Question 16

Excessive blockade of dopamine D2 receptors will eventually result in:

A) Downregulation of receptors
B) Schizoprenia
C) Extrapyramidal syndrome
D) Anxiety

Question 17

A person taking an atypical antipsychotic medication could be expected to develop all of the following metabolic disorders except:

A) Weight gain
B) Anemia
C) Hyperlipidemia
D) Diabetes mellitus

Question 18

The manic phase of manic depressive personality disorder can best be treated with which class of antipsychotic medication?

A) Butyrophenones
B) Phenothiazines
C) Thioxanthenes
D) Atypical antipsychotics

Question 19

A potentially fatal condition associated with antipsychotic use characterized by hyperthermia,muscular rigidity,and catatonia:

A) Neuroleptic malignant syndrome
B) Dystonic reactions
C) Akathesia
D) Tardive dyskinesia

Question 20

One main characteristic of phenothiazine antipsychotics is their ability to:

A) Block dopamine D2 receptors to a greater degree than serotonin 5HT_2A receptors
B) Block cholinergic receptors to a greater degree than serotonin 5HT_2A receptors
C) Block serotonin 5HT_2A receptors to a greater degree than dopamine D2 receptors
D) Block histamine receptors to a greater degree than serotonin 5HT_2A receptors