Deck 5: Antidepressant Drugs

Question 1

Availability of newer antidepressants has:

A)decreased the number of treatment-resistant people with major depression.
B)increased the efficacy of antidepressants.
C)accelerated the onset of action of antidepressants.
D)improved the side-effect profile.

Answer 1

D

Question 2

Compared to SSRIs,TCAs are:

A)more effective and less expensive.
B)no more effective and more expensive.
C)more effective and more expensive.
D)no more effective but less expensive.

Answer 2

D

Question 3

The dry mouth,memory impairment,and confusion associated with use of tricyclic antidepressants are a result of action on the following neurotransmitter:

A)norepinephrine.
B)serotonin.
C)histamine.
D)acetylcholine.

Answer 3

D

Question 4

Imipramine (Tofranil)and desipramine (Norpramin)are examples of:

A)MAOIs.
B)SSRIs.
C)second-generation antidepressants.
D)TCAs.

Question 5

First-generation tricyclic antidepressants are defined by a commonality in basic:

A)effect.
B)mechanism of action.
C)structure.
D)site of action.

Question 6

TCAs are effective in treating:

A)anxiety.
B)depression.
C)pain.
D)All of the answers are correct.

Question 7

Tricyclic antidepressants have all of the following actions,EXCEPT:

A)blocking serotonin receptors.
B)blocking histamine receptors.
C)blocking acetylcholine receptors.
D)blocking norepinephrine reuptake.

Question 8

The mechanism of action of newer antidepressants like Prozac and Zoloft is:

A)blockade of postsynaptic receptors.
B)inhibition of degradation by enzymes.
C)inhibition of neurotransmitter reuptake.
D)inhibition of neurotransmitter release.

Question 9

The therapeutic mechanism of action of the tricyclic antidepressants is:

A)blockade of postsynaptic receptors.
B)inhibition of degradation by enzymes.
C)inhibition of neurotransmitter reuptake.
D)inhibition of neurotransmitter release.

Question 10

MAO-A's mechanism of action involves ________; MAO-B's mechanism of action involves ________.

A)norepinephrine; serotonin
B)dopamine; serotonin
C)norepinephrine; dopamine
D)dopamine; norepinephrine

Question 11

Feeling dizzy when standing up too quickly is a side effect of the:

A)MAOIs.
B)SSRIs.
C)second-generation antidepressants.
D)TCAs.

Question 12

The major side effect associated with use of MAOIs is:

A)heart arrhythmias.
B)memory impairment.
C)cardiac toxicity.
D)hypertension.

Question 13

The mechanism of action of the MAOIs is:

A)blockade of postsynaptic receptors.
B)inhibition of degradation by enzymes.
C)inhibition of neurotransmitter reuptake.
D)inhibition of neurotransmitter release.

Question 14

The tricyclic antidepressants differ from Prozac and Zoloft in that they also have major effects on the following neurotransmitter:

A)glutamate.
B)norepinephrine.
C)serotonin.
D)GABA.

Question 15

Impairment of memory is a side effect clearly associated with the use of:

A)TCAs.
B)SSRIs.
C)second-generation antidepressants.
D)MAOIs.

Question 16

The first-generation antidepressants consist of:

A)TCAs only.
B)MAOIs only.
C)atypical antidepressants.
D)TCAs and MAOIs.

Question 17

Dangerous interactions with aged cheese and other food products containing tyramine is associated with:

A)TCAs.
B)SSRIs.
C)atypical second-generation antidepressants.
D)MAOIs.

Question 18

Cardiac toxicity is an effect most clearly associated with overdose of:

A)TCAs.
B)SSRIs.
C)second-generation antidepressants.
D)MAOIs.

Question 19

The "neurogenic theory of depression" stems from recent findings that in the mature brain:

A)neurons are incapable of repairing themselves.
B)neurons are incapable of being newly produced.
C)neurons can neither be repaired nor produced.
D)neurons are capable of being repaired and produced.

Question 20

In depressed patients,tricyclic antidepressants ________; in nondepressed subjects,tricyclic antidepressants ________.

A)elevate mood; do not affect mood
B)elevate mood; elevate mood
C)do not affect mood; do not affect mood
D)do not affect mood; elevate mood

Question 21

The mechanism of action of the antidepressants Wellbutrin and Zyban is unique among antidepressants in that they also affect:

A)acetylcholine.
B)serotonin.
C)dopamine.
D)All of the answers are correct.

Question 22

Today,anxiety disorders are most often treated with anxiolytics,not antidepressants.

Question 23

Of the following classes of antidepressant drugs,the one associated with the highest incidence (up to 80% of patients taking the drug)of sexual dysfunction is:

A)TCAs.
B)SSRIs.
C)MAOIs.
D)atypical second-generation antidepressants.

Question 24

One of the most important side effects of fluoxetine (Prozac)is:

A)anxiolysis.
B)anxiogenesis.
C)analgesia.
D)sedation.

Question 25

The dual-acting antidepressant Effexor EX (extended release)is FDA-approved for the treatment of:

A)bipolar disorder.
B)panic disorder.
C)decreased libido.
D)ADHD.

Question 26

Which of the following statements is TRUE?

A)TCAs,but not SSRIs,are useful in treating clinical pain syndromes.
B)SSRIs,but not TCAs,are useful in treating clinical pain syndromes.
C)Both TCAs and SSRIs are useful in treating clinical pain syndromes.
D)Neither TCAs nor SSRIs are useful in treating clinical pain syndromes.

Question 27

Depression can physically shrink the hippocampus.

Question 28

Tianeptine is a unique antidepressant in that its mechanism of action is the:

A)blockade of presynaptic reuptake of norepinephrine.
B)facilitation of presynaptic reuptake of norepinephrine.
C)blockade of presynaptic reuptake of serotonin.
D)facilitation of presynaptic reuptake of serotonin.

Question 29

The newer antidepressants have reduced the number of treatment-resistant people with depression.

Question 30

The sensation of electric shocks is associated with discontinuation of:

A)tricyclic antidepressants.
B)SSRIs.
C)MAOIs.
D)atypical second-generation antidepressants.

Question 31

The SSRI most associated with "serotonin syndrome" is:

A)Zoloft.
B)Prozac.
C)Lovox.
D)Paxil.

Question 32

The atypical second-generation antidepressant Effexor (venlafaxine)differs most from the tricyclic antidepressants in its effect (or lack thereof)on the neurotransmitter:

A)dopamine.
B)serotonin.
C)norepinephrine.
D)acetylcholine.

Question 33

Selective norepinephrine reuptake inhibitors (SNRIs)are:

A)ineffective in treating depression.
B)ineffective in treating ADHD.
C)effective in treating depression,but not ADHD.
D)effective in treating depression and ADHD.

Question 34

Antidepressants relieve depressed mood by reversing stress-induced neuronal damage.

Question 35

The major problem with biological amine theories of depression relates to neuronal injury.

Question 36

The dual-acting antidepressant Serzon (nefazodone)has a unique initial mechanism of action that ________; prolonged use results in ________.

A)inhibits neurotransmitter reuptake; up regulation of receptors
B)inhibits neurotransmitter reuptake; down regulation of receptors
C)blocks receptors; up regulation of receptors
D)blocks receptors; down regulation of receptors

Question 37

A deficiency of the B vitamin folate:

A)increases monoamine levels and the risk of depression.
B)decreases monoamine levels and the risk of depression.
C)increases monoamine levels and decreases the risk of depression.
D)decreases monoamine levels and increases the risk of depression.

Question 38

Antidepressant drugs can repair stress-induced neuronal damage.

Question 39

Potential antidepressants include:

A)substance P agonists and 5-HT1 agonists.
B)substance P antagonists and 5-HT1 agonists.
C)substance P agonists and 5-HT1 antagonists.
D)substance P antagonists and 5-HT1 antagonists.

Question 40

The various SSRIs (Prozac,Zoloft,Paxil)differ in terms of:

A)efficacy but not mechanism of action.
B)mechanism of action but not efficacy.
C)neither efficacy nor mechanism of action.
D)both efficacy and mechanism of action.

Question 41

No antidepressants exist that specifically and solely affect norepinephrine.

Question 42

The SSRIs are more effective than older TCAs.

Question 43

First-generation tricyclic antidepressants are defined by a commonality in basic mechanism.

Question 44

The major side effects of TCAs result from effects on the neurotransmitters acetylcholine and histamine.

Question 45

The dual-action antidepressant Serzone blocks neurotransmitter reuptake as well as 5-HT₂ receptors.

Question 46

TCAs interact dangerously with adrenalinelike drugs.

Question 47

All the TCAs affect both the neurotransmitters norepinephrine and serotonin.

Question 48

Long-term antidepressant use in children and adolescents appears to be associated with an increased risk of suicide.

Question 49

A person can become dependent on SSRIs,experiencing withdrawal effects upon termination.

Question 50

TCAs,but not SSRIs,are effective in treating anxiety disorders such as panic.

Question 51

The dietary supplement SAMe is effective in treating depression.

Question 52

The difference between Celexa and Paxil relates to efficacy.

Question 53

A folate deficiency may increase the risk of depression.

Question 54

Both blockade of and increase of serotonin reuptake has antidepressant action.

Question 55

The first-generation antidepressants have a more favorable profile of toxicity than SSRIs.

Question 56

Most first-generation antidepressants have little effect on the neurotransmitter dopamine.

Question 57

In nondepressed individuals,TCAs are positively reinforcing.

Question 58

Some SSRIs interfere with cancer treatment.

Question 59

SSRIs block some postsynaptic serotonin receptors.