Deck 17: The Organic Chemistry of Metabolic Pathways
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Deck 17: The Organic Chemistry of Metabolic Pathways
1
Consider the following reaction.
Which of the following describes this reaction?
A) is so strongly exergonic that it does not require a catalyst
B) is an exergonic reaction not coupled to any other reaction
C) is an endergonic reaction that takes place because it is coupled to the exergonic hydrolysis of ATP
D) is an exergonic reaction that is coupled to the endergonic hydrolysis of ATP
Which of the following describes this reaction?A) is so strongly exergonic that it does not require a catalyst
B) is an exergonic reaction not coupled to any other reaction
C) is an endergonic reaction that takes place because it is coupled to the exergonic hydrolysis of ATP
D) is an exergonic reaction that is coupled to the endergonic hydrolysis of ATP
C
2
What amino acid is the following a-keto acid derived from?
glutamic acid 
3
Which group of small molecules best fit the boxes associated with the reaction shown?
a b
A) ADP + 2 Pi ATP
B) NAD+ NADH
C) NADP+ NADPH
D) FAD FADH2
a bA) ADP + 2 Pi ATP
B) NAD+ NADH
C) NADP+ NADPH
D) FAD FADH2
B
4
Which group of small molecules best fit the boxes associated with the reaction shown?
a b
A) GDP GTP
B) NADP+ NADPH
C) ADP + Pi ATP
D) FAD FADH2
a bA) GDP GTP
B) NADP+ NADPH
C) ADP + Pi ATP
D) FAD FADH2
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5
Consider the deamination of serine to answer the following questions.


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6
The reaction of fructose 1,6-bisphosphate to give glyceraldehyde-3-phosphate and dihydroxyacetone phosphate is an example of
A) a reverse aldol condensation
B) hydrolysis
C) oxidation
D) dehydration
A) a reverse aldol condensation
B) hydrolysis
C) oxidation
D) dehydration
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7
What product would be obtained from enzymatic transamination of 3-hydroxy-2-ketopropanoic acid? 

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8
A coenzyme frequently encountered in transamination reactions is
A) tetrahydrofolate
B) pyridoxal phosphate
C) thiamine pyrophosphate
D) biotin
A) tetrahydrofolate
B) pyridoxal phosphate
C) thiamine pyrophosphate
D) biotin
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9
What reaction does glutamate dehydrogenase (GDH) catalyze?
A) The oxidative deamination of glutamate to yield a-ketoglutarate.
B) Phosphorylation of carbamate to yield carbamoyl phosphate.
C) The amidation of the g carboxyl group of glutamate to form glutamine.
D) The deadenylation of glutamine synthetase (GS).
E) The adenylation of glutamine synthetase.
A) The oxidative deamination of glutamate to yield a-ketoglutarate.
B) Phosphorylation of carbamate to yield carbamoyl phosphate.
C) The amidation of the g carboxyl group of glutamate to form glutamine.
D) The deadenylation of glutamine synthetase (GS).
E) The adenylation of glutamine synthetase.
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10
The key functional group in the PLP-dependent transamination of an a-amino acid is an activated
A) amine
B) imine
C) amide
D) enamine
A) amine
B) imine
C) amide
D) enamine
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11
Which group of small molecules best fit the boxes associated with the reaction shown?
a b c
A) ATP ADP H2O
B) NADH NAD+ Pi
C) NAD+ NADH H2O
D) NAD+ NADH Pi
a b cA) ATP ADP H2O
B) NADH NAD+ Pi
C) NAD+ NADH H2O
D) NAD+ NADH Pi
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12
Which enzyme catalyzes the reaction shown? 
A) an epimerase
B) an isomerase
C) a mutase
D) a dehydrogenase

A) an epimerase
B) an isomerase
C) a mutase
D) a dehydrogenase
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13
Consider the structure of amylopectin below to answer the following questions.


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14
Which group of small molecules best fit the boxes associated with the reaction shown?
a b
A) ADP + 2 Pi ATP
B) NAD+ NADH
C) ATP ADP + 2 Pi
D) FAD FADH2
a bA) ADP + 2 Pi ATP
B) NAD+ NADH
C) ATP ADP + 2 Pi
D) FAD FADH2
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15
Instructions: Consider the reaction below to answer the following question(s).
Refer to instructions. This reaction proceeds through a common enol structure. Draw the structure of the glucose/fructose enol.
Refer to instructions. This reaction proceeds through a common enol structure. Draw the structure of the glucose/fructose enol. Unlock Deck
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16
The formation of amino acids from proteins
A) occurs during anabolism.
B) is endergonic.
C) occurs during digestion.
D) is a cellular process.
E) all of these
A) occurs during anabolism.
B) is endergonic.
C) occurs during digestion.
D) is a cellular process.
E) all of these
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17
Consider the reaction below to answer the following questions.


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18
Many biological reactions are endergonic. Explain how it is possible that these reactions occur spontaneously.
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19
During the complete catabolism of a molecule of glucose, the ultimate fate of the carbon atoms are
A) pyruvate
B) AcetylCoA
C) carbon dioxide
D) fructose-6-phosphate
E) a, b or c
A) pyruvate
B) AcetylCoA
C) carbon dioxide
D) fructose-6-phosphate
E) a, b or c
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20
When acetyl-CoA reacts with oxaloacetate to form citrate
A) a new carbon-carbon bond is formed
B) an oxidative decarboxylation reaction takes place
C) a dehydration reaction takes place
D) a rearrangement takes place
A) a new carbon-carbon bond is formed
B) an oxidative decarboxylation reaction takes place
C) a dehydration reaction takes place
D) a rearrangement takes place
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21
Draw and name the major product of the reaction of a-glucose with ATP.
a-glucose-6-phosphate
a-glucose-6-phosphate
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22
Draw the product of the following reaction, which is involved in the catabolism of triacylglycerols. 

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23
Instructions: Consider the reaction below to answer the following question(s).
Refer to instructions. Write the mechanism for this isomerization.
Refer to instructions. Write the mechanism for this isomerization. Unlock Deck
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24
How many molecules of acetyl CoA are produced in the catabolism of stearic acid?
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25
Instructions: Consider the reaction below to answer the following questions:
Refer to instructions. This reaction is an example of:

Refer to instructions. This reaction is an example of:
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26
What is the structure of the a-keto acid formed by transamination of the amino acid isoleucine? 

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27
All of the following describe b-oxidation, except:
A) Two-carbon units are eliminated during each cycle.
B) The process employs NAD+ as an oxidant.
C) The process is the primary route to fatty acid degradation.
D) The 2-carbon groups are eliminated from the methyl end of the fatty acid.
E) Fatty acids are attached to coenzyme A during the process.
A) Two-carbon units are eliminated during each cycle.
B) The process employs NAD+ as an oxidant.
C) The process is the primary route to fatty acid degradation.
D) The 2-carbon groups are eliminated from the methyl end of the fatty acid.
E) Fatty acids are attached to coenzyme A during the process.
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28
Instructions: Consider the reaction below to answer the following question(s).
Refer to instructions. The isomerization of glucose 6-phosphate to fructose 6-phosphate is an example of:

Refer to instructions. The isomerization of glucose 6-phosphate to fructose 6-phosphate is an example of:
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29
All of the following are byproducts of b-oxidation, except:
A) Acetyl CoA
B) ADP
C) NADH
D) FADH2
E) All of these are byproducts of b-oxidation.
A) Acetyl CoA
B) ADP
C) NADH
D) FADH2
E) All of these are byproducts of b-oxidation.
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30
Instructions: Match a term or structure from the list below to each of the following definitions or names.
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31
Draw the structure of the ultimate organic glycolysis product of a-glucose. 

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32
Instructions: Consider the reaction below to answer the following questions:
Refer to instructions. Draw arrows on the structure below showing electron flow in this reaction. 
Refer to instructions. Draw arrows on the structure below showing electron flow in this reaction. 
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33
The source of oxygen for b-oxidation is:
A) CO2
B) O2
C) Peroxide
D) Water
E) None of these is the source of oxygen for b-oxidation.
A) CO2
B) O2
C) Peroxide
D) Water
E) None of these is the source of oxygen for b-oxidation.
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35
Match between columns
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