Zoology 10th Edition by Stephen Miller,John Harley

Exercise 18

Hydrophobic hormones, such as peptides and amino acids, bind externally to the plasma membrane receptors that activate protein kinases directly or that operate through second-messenger systems such as cAMP. Steroids, which are lipophilic, pass through a target cell's plasma membrane and bind to intracellular receptor proteins. The hormone-receptor complex then binds to the hormone response element of the target gene.
How can a single hormone, such as epinephrine, have different effects in different cells or tissues?